ArticleJournal of bacteriology2011
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues inMarine drugs · 2018Article
- Article
- Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937.Microbial biotechnology · 2017Article
- Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.Microbial cell factories · 2017Article
- Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103.Scientific reports · 2017Article
- Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.Microbial cell factories · 2016Article
- New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis.Microbial cell factories · 2016Article
- The many roles of glutamate in metabolism.Journal of industrial microbiology & biotechnology · 2016Review
- Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.Microbial cell factories · 2016Article
- Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.Microbial biotechnology · 2014Article
- Insights into the roles of exogenous glutamate and proline in improving streptolydigin production of Streptomyces lydicus with metabolomic analysis.Journal of industrial microbiology & biotechnology · 2013Article
- Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.The Journal of biological chemistry · 2013Article
- Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.Microbial biotechnology · 2012Article
- Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.Journal of the American Chemical Society · 2011Article
- Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic acid streptolydigin in Streptomyces lydicus. Inactivation of slgZ led to a novel streptolydigin derivative. Overexpression of slgZ, slgM, or both in S. lydicus led to a considerable increase in streptolydigin production.
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