ArticleCephalalgia : an international journal of headache2011
Migraine features, associated symptoms and triggers: a principal component analysis in the Women's Health Study.
Article in Cephalalgia : an international journal of headache, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.Headache · 2020Pooled it
- Alcohol Use as a Comorbidity and Precipitant of Primary Headache: Review and Meta-analysis.Current pain and headache reports · 2017Pooled it
- Analysis of Trigger Factors in Episodic Migraineurs Using a Smartphone Headache Diary Applications.PloS one · 2016Trial
- Observational
- Assessment of Chocolate, Cheese, and Caffeine as Migraine Triggers: A Systematic Review and Meta-Analysis of Patient-Reported Trigger Rates.Journal of nutrition and metabolism · 2026Review
- Unmasking the relationship between CGRP and glutamate: from peripheral excitation to central sensitization in migraine.The journal of headache and pain · 2025Review
- Classifying migraine subtypes and their characteristics by latent class analysis using data of a nation-wide population-based study.Scientific reports · 2021Article
- Comparison of cervical muscle isometric force between migraine subgroups or migraine-associated neck pain: a controlled study.Scientific reports · 2021Article
- Article
- Review
- Review
- Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study.Scientific reports · 2020Article
- Visual Field Losses in Patients with Migraine without Aura and Tension-Type Headache.Neuro-ophthalmology (Aeolus Press) · 2017Article
- Selectivity in genetic association with sub-classified migraine in women.PLoS genetics · 2014Article
- Reduction in perceived stress as a migraine trigger: testing the "let-down headache" hypothesis.Neurology · 2014Article
- Migraine and triggers: post hoc ergo propter hoc?Current pain and headache reports · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
aimsMigraine has a wide clinical spectrum. Our aim was to group information on migraine characteristics into meaningful components and to identify key components of the migraine phenotype.
methodsWe performed two principal component analyses, one among participants in the Women's Health Study enrollment cohort and one in a sub-cohort with additional migraine-specific information.
resultsAmong the 9427 women with migraine attack-related information at enrollment, the three most important components pertained to central nervous system (CNS) sensitization, attack frequency/pain location and aura/visual phenomena. In the subgroup of 1675 women with more detailed information, food triggers and unspecific symptoms constituted two principal components that explain more of the variance of the migraine phenotype than the three attack-related components.
conclusionsOur results indicate that information on migraine-associated features, symptoms and triggers is highly correlated, allowing the extraction of principal components. Migraine attack-related symptoms are best summarized by symptoms related to CNS sensitization, attack frequency/pain location and aura/visual phenomena. Taking a more general view, unspecific symptoms and food triggers appear to carry stronger importance in characterizing the migraine phenotype. These components are useful for future research on the pathophysiology and genetics of migraine and may have implications for diagnosing and treating patients.
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Registered trials
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