ArticleBrain : a journal of neurology2011
Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy.
Article in Brain : a journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Motor co-activation in siblings of patients with juvenile myoclonic epilepsy: an imaging endophenotype?Brain : a journal of neurology · 2014Trial
- Global burden of epilepsy attributable to neonatal disorders in children from 1990 to 2021.iScience · 2026Article
- Altered neurostructural development in magnetic resonance imaging-negative pediatric epilepsy: A large-scale multicenter study of 1919 children.Epilepsia · 2026Article
- Deep Learning-Based Tract Classification of Preoperative DWI Tractography Advances the Prediction of Short-Term Postoperative Language Improvement in Children With Drug-Resistant Epilepsy.IEEE transactions on bio-medical engineering · 2025Article
- Prediction of Post Traumatic Epilepsy Using MR-Based Imaging Markers.Human brain mapping · 2024Article
- Widespread, depth-dependent cortical microstructure alterations in pediatric focal epilepsy.Epilepsia · 2024Article
- Brain volumes and white matter diffusion across the adult lifespan in temporal lobe epilepsy.Annals of clinical and translational neurology · 2023Article
- Complement Drives Chronic Inflammation and Progressive Hydrocephalus in Murine Neonatal Germinal Matrix Hemorrhage.International journal of molecular sciences · 2023Article
- Neuroanatomic Markers of Posttraumatic Epilepsy Based on MR Imaging and Machine Learning.AJNR. American journal of neuroradiology · 2022Article
- Morphological Changes of Frontal Areas in Male Individuals With HIV: A Deformation-Based Morphometry Analysis.Frontiers in neurology · 2022Article
- UltraHigh Field MR Imaging in Epilepsy.Magnetic resonance imaging clinics of North America · 2021Review
- Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes.NeuroImage. Clinical · 2020Article
- Thalamic volume reduction in drug-naive patients with new-onset genetic generalized epilepsy.Epilepsia · 2018Article
- Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes.Korean journal of pediatrics · 2016Review
- Effects of long-term treatment on brain volume in patients with obstructive sleep apnea syndrome.Human brain mapping · 2016Article
- Cortical and subcortical brain alterations in Juvenile Absence Epilepsy.NeuroImage. Clinical · 2016Article
- Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy.BJPsych open · 2015Article
- Evaluation of subcortical grey matter abnormalities in patients with MRI-negative cortical epilepsy determined through structural and tensor magnetic resonance imaging.BMC neurology · 2014Article
- Regional brain volumes and cognition in childhood epilepsy: does size really matter?Epilepsy research · 2014Article
- Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic structural abnormalities.Epilepsia · 2013Article
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Authors and funding
7 authors.
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Abstract
Epilepsy is a prevalent childhood neurological disorder, but there are few prospective quantitative magnetic resonance imaging studies examining patterns of brain development compared to healthy controls. Controlled prospective investigations initiated at or near epilepsy onset would best characterize the nature, timing and course of neuroimaging abnormalities in paediatric epilepsy. In this study, we report the results of a deformation-based morphometry technique to examine baseline and 2-year prospective neurodevelopmental brain changes in children with new and recent onset localization-related epilepsies (n = 24) and idiopathic generalized epilepsies (n = 20) compared to healthy controls (n = 36). Children with epilepsy demonstrated differences from controls in baseline grey and white matter volumes suggesting antecedent anomalies in brain development, as well as abnormal patterns of prospective brain development that involved not only slowed white matter expansion, but also abnormalities of cortical grey matter development involving both greater and lesser volume changes compared to controls. Furthermore, abnormal neurodevelopmental changes extended outside the cortex affecting several subcortical structures including thalamus, cerebellum, brainstem and pons. Finally, there were significant differences between the epilepsy syndromes (localization-related epilepsies and idiopathic generalized epilepsies) with the idiopathic generalized epilepsies group showing a more disrupted pattern of brain structure both at baseline and over the 2-year interval.
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