ArticleInvestigative ophthalmology & visual science2011
Genetic dissection of the Gpnmb network in the eye.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Genetic Basis of Pigment Dispersion Syndrome and Pigmentary Glaucoma: An Update and Functional Insights.Genes · 2024Review
- Exploring Early-Stage Retinal Neurodegeneration in Murine Pigmentary Glaucoma: Insights From Gene Networks and miRNA Regulation Analyses.Investigative ophthalmology & visual science · 2023Article
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- Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma.Frontiers in genetics · 2020Article
- Investigating a downstream gene ofMolecular vision · 2019Article
- The genetic dissection ofMolecular vision · 2018Article
- Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.Nature communications · 2017Article
- Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice.Alcohol (Fayetteville, N.Y.) · 2017Article
- A Spontaneous Mutation inFrontiers in pharmacology · 2017Article
- Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas.Molecular vision · 2016Article
- Isolation and Molecular Profiling of Primary Mouse Retinal Ganglion Cells: Comparison of Phenotypes from Healthy and Glaucomatous Retinas.Frontiers in aging neuroscience · 2016Article
- Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.PloS one · 2016Article
- Iris transillumination defect and its gene modulators do not correlate with intraocular pressure in the BXD family of mice.Molecular vision · 2016Article
- Natural Bioadhesive Biodegradable Nanoparticle-Based Topical Ophthalmic Formulations for Management of Glaucoma.Translational vision science & technology · 2015Article
- Novel topical ophthalmic formulations for management of glaucoma.Pharmaceutical research · 2013Article
- Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains.Pigment cell & melanoma research · 2013Article
- Complex interactions of Tyrp1 in the eye.Molecular vision · 2011Article
- Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo use a systematic genetics approach to investigate the regulation of Gpnmb, a gene that contributes to pigmentary dispersion syndrome (PDS) and pigmentary glaucoma (PG) in the DBA/2J (D2) mouse.
methodsGlobal patterns of gene expression were studied in whole eyes of a large family of BXD mouse strains (n = 67) generated by crossing the PDS- and PG-prone parent (DBA/2J) with a resistant strain (C57BL/6J). Quantitative trait locus (eQTL) mapping methods and gene set analysis were used to evaluate Gpnmb coexpression networks in wild-type and mutant cohorts.
resultsThe level of Gpnmb expression was associated with a highly significant cis-eQTL at the location of the gene itself. This autocontrol of Gpnmb is likely to be a direct consequence of the known premature stop codon in exon 4. Both gene ontology and coexpression network analyses demonstrated that the mutation in Gpnmb radically modified the set of genes with which Gpnmb expression is correlated. The covariates of wild-type Gpnmb are involved in biological processes including melanin synthesis and cell migration, whereas the covariates of mutant Gpnmb are involved in the biological processes of posttranslational modification, stress activation, and sensory processing.
conclusionsThese results demonstrated that a systematic genetics approach provides a powerful tool for constructing coexpression networks that define the biological process categories within which similarly regulated genes function. The authors showed that the R150X mutation in Gpnmb dramatically modified its list of genetic covariates, which may explain the associated ocular pathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.