ArticleJournal of pain and symptom management2011
The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors.
Article in Journal of pain and symptom management, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Activity Behaviours in Patients With Malignant Pleural Effusion: Relationships With Quality of Life, and Respiratory Symptoms, and Survival
Acupressure for Cough in Lung Cancer Survivors: A Randomized Controlled Trial
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Systematic review of the literature on the occurrence and characteristics of dyspnea in oncology patients.Critical reviews in oncology/hematology · 2023Pooled it
- Association between physical activity and patient-reported outcome measures in patients with lung cancer: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- Telephone interventions for symptom management in adults with cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Understanding factors influencing physical activity and exercise in lung cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Effects of Bojungikki-Tang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors: a randomized pilot study.BMC cancer · 2025Trial
- Characterization of multidimensional dyspnea in advanced lung cancer with moderate to severe dyspnea-related functional impairment: a latent profile analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Symptom Cluster Trajectories of Cough, Shortness of Breath, and Disturbed Sleep in Patients Undergoing Lung Cancer Surgery: A Longitudinal Study.Annals of surgical oncology · 2026Article
- Using actigraphy to evaluate physical activity in patients with pleural effusion: a pilot study.Journal of thoracic disease · 2026Article
- Quantifying the Degree of Fatigue in People Reporting Symptoms of Post-COVID-19 Syndrome: Results from a Rasch Analysis.Physiotherapy Canada. Physiotherapie Canada · 2025Article
- Activity behaviours and quality of life in patients with malignant pleural effusion.ERJ open research · 2025Article
- Prognosis and risk factor assessment of patients with advanced lung cancer with low socioeconomic status: model development and validation.BMC cancer · 2024Article
- Non-invasive surrogate markers of pulmonary hypertension are associated with poor survival in patients with cancer.BMJ open respiratory research · 2024Observational
- Potential Therapeutic Role of Respiratory Muscle Training in Dyspnea Management of Cancer Survivors: A Narrative Review.World journal of oncology · 2024Review
- Article
- Safety and Efficacy ofInternational journal of environmental research and public health · 2023Article
- Distinct Shortness of Breath Profiles in Oncology Outpatients Undergoing Chemotherapy.Journal of pain and symptom management · 2023Article
- Perioperative pregabalin reduced fatigue scores after thoracoscopic pneumonectomy in a RCT of NSCLC patients.American journal of cancer research · 2023Article
- Shortness of Breath on Day 1 After Surgery Alerting the Presence of Early Respiratory Complications After Surgery in Lung Cancer Patients.Patient preference and adherence · 2022Article
- Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- A Proposed Theory of Symptom Cluster Management.Belitung nursing journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
contextAggregates of concurrent symptoms, known as symptom clusters (SxCls), are reported to have prognostic capabilities beyond that of single symptom alone. A SxCl of fatigue, dyspnea, and cough has been delineated in a number of lung cancer cohorts.
objectivesThe objective of this study was to characterize this SxCl's predictive value for important clinical outcomes relative to that of its component symptoms.
methodsAnalysis of an eight-year prospective cohort study that assessed 2405 patients with LC for self-reported symptom burden, employment status, and physical activity with the Baecke questionnaire, and overall quality of life (QoL) was undertaken using nested Cox and generalized linear multilevel mixed models. Models were adjusted for longitudinally assessed demographics, cancer progression and tobacco use, and cancer progression.
resultsThe SxCl, as well as its individual symptoms and symptom pairs, were all negatively associated with survival in Cox models of Years 1-3 after diagnosis. Only in Year 3 did the SxCl prognosticate survival (and then marginally) better than single symptoms or symptom pairs; fatigue was strongly associated (P≤0.0005) with survival at all time points. The SxCl was not predictive of participants' employment status, physical activity, or QoL, whereas the presence of fatigue, dyspnea, or their combination was strongly associated with these outcomes.
conclusionFatigue and dyspnea are strongly associated with poor clinical outcomes in LC survivors; however, a SxCl that includes fatigue, dyspnea, and cough as part as its components does not appear to significantly improve their predictive capability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.