ArticleCell1990
The roles of Drosophila cyclins A and B in mitotic control.
Article in Cell, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
152 citing papers in PubMed, 428 citations in OpenAlex.
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- Polyploidy in development and tumor models in Drosophila.Seminars in cancer biology · 2022Review
- Modulating the bicoid gradient in space and time.Hereditas · 2021Article
- Temporal Gradients Controlling Embryonic Cell Cycle.Biology · 2021Review
- Single-cell transcriptomics of theeLife · 2021Article
- RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis.PLoS genetics · 2019Article
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- Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.The Journal of cell biology · 2018Article
- The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.PLoS genetics · 2017Article
- Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.Trends in genetics : TIG · 2016Review
- Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.Molecular biology of the cell · 2016Article
- Protein-mRNA interactome capture: cartography of the mRNP landscape.F1000Research · 2016Review
- Trithorax regulates systemic signaling during Drosophila imaginal disc regeneration.Development (Cambridge, England) · 2015Article
- Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.Current biology : CB · 2015Article
- Spatial reorganization of the endoplasmic reticulum during mitosis relies on mitotic kinase cyclin A in the early Drosophila embryo.PloS one · 2015Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.