ArticlePharmacology, biochemistry, and behavior2011
Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice.
Article in Pharmacology, biochemistry, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Influence of SSRI and SNRI co-prescription on benzodiazepine prescription trajectories.Drug and alcohol dependence reports · 2025Article
- Review
- Synergistic effect between citalopram and muscimol upon induction of anxiolytic- and antidepressant-like effects in male mice: An isobologram analysis.IBRO neuroscience reports · 2024Article
- Diazepam effects on anxiety-related defensive behavior of male and female high and low open-field activity inbred mouse strains.Physiology & behavior · 2023Article
- Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.Brain sciences · 2023Article
- Article
- Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats.Pflugers Archiv : European journal of physiology · 2022Article
- Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity.Frontiers in psychiatry · 2022Article
- To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays.Frontiers in behavioral neuroscience · 2020Review
- Perseveration in a spatial-discrimination serial reversal learning task is differentially affected by MAO-A and MAO-B inhibition and associated with reduced anxiety and peripheral serotonin levels.Psychopharmacology · 2017Article
- Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine.Frontiers in behavioral neuroscience · 2017Article
- Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.Behavioural brain research · 2016Article
- Preclinical animal anxiety research - flaws and prejudices.Pharmacology research & perspectives · 2016Review
- Effects of acute or repeated paroxetine and fluoxetine treatment on affective behavior in male and female adolescent rats.Psychopharmacology · 2015Article
- Prototypical anxiolytics do not reduce anxiety-like behavior in the open field in C57BL/6J mice.Pharmacology, biochemistry, and behavior · 2015Article
- The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression.Translational psychiatry · 2015Article
- Pharmacology of serotonin and female sexual behavior.Pharmacology, biochemistry, and behavior · 2014Review
- Effect of desipramine and citalopram treatment on forced swimming test-induced changes in cocaine- and amphetamine-regulated transcript (CART) immunoreactivity in mice.Neurochemical research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Selective serotonin re-uptake inhibitors (SSRIs), which are used commonly to treat anxiety disorders, have characteristic anxiogenic effects following acute administration. Treatment with anxiolytic benzodiazepines (BZs) may reduce these effects, although little is known about potential drug interactions. Our study evaluated acute anxiogenic-like effects of SSRIs, alone and combined with a BZ. Adult male BALB/c mice received fluoxetine (3.0-30.0mg/kg, i.p.) or citalopram (3.0-30.0mg/kg, i.p.) alone or in combination with diazepam (0.3-10.0mg/kg, i.p.), after which they were evaluated with the light/dark and open-field tests for anxiogenesis/anxiolysis. In addition, release of the stress hormone corticosterone was assessed following combined SSRI/BZ administration. In the light/dark and open-field tests, acute SSRIs produced a behavioral profile consistent with anxiogenesis, while diazepam produced an anxiolytic-like profile. Pre-treatment with diazepam (0.3-10mg/kg) reversed the effects of an anxiogenic-like dose of an SSRI (18mg/kg fluoxetine, 30mg/kg citalopram) in both light/dark and open-field tests. Diazepam, fluoxetine or citalopram, and their combination all significantly increased plasma corticosterone levels to the same degree. These findings suggest that a BZ-type drug can attenuate acute anxiogenic-like effects of an SSRI via a mechanism independent of corticosterone regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.