ArticleBiomaterials2011
Multinucleated giant cells from fibroblast cultures.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Unraveling and Harnessing the Immune Response at the Cell-Biomaterial Interface for Tissue Engineering Purposes.Advanced healthcare materials · 2024Review
- A Lombard Variety of Sweet Pepper Regulating Senescence and Proliferation: The Voghera Pepper.Nutrients · 2024Article
- Multinucleated giant cells of bladder mucosa are modified telocytes: Diagnostic and immunohistochemistry algorithm and relation to PD-L1 expression score.World journal of clinical cases · 2023Article
- Effect of Nanobubble Presence on Murine Fibroblasts and Human Leukemia Cell Cultures.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells.Scientific reports · 2022Article
- Potential functions of histone H3.3 lysine 56 acetylation in mammals.Epigenetics · 2022Article
- Mid-Gestation lethality ofInternational journal of molecular sciences · 2020Article
- Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo.Oncogene · 2018Article
- Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration.Biomaterials · 2017Article
- Regulation of cell-cell fusion by nanotopography.Scientific reports · 2016Article
- Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.Journal of biomedical materials research. Part A · 2015Article
- Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell Line.BioMed research international · 2015Article
- Giant cell fibroma of tongue: understanding the nature of an unusual histopathological entity.Case reports in dentistry · 2014Article
- Fibroblasts cultured on nanowires exhibit low motility, impaired cell division, and DNA damage.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Article
Corrections and comments
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2 authors.
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Abstract
Many multinucleated giant cells are well-known to form from macrophage origin. Those formed from other cell types are less described, but may be as prevalent in pathological tissue. Giant multinucleated cells derived from secondary and primary fibroblast sources in various cultures with similar characteristics to foreign body giant cells are reported. Secondary-transformed NIH 3T3 fibroblasts rapidly fuse within 24 h in contact co-cultures with RAW 264.7 immortalized macrophages, while 3T3 monocultures, non-contact (transwell) co-cultures, and macrophage-conditioned media-treated 3T3 monocultures all do not fuse. Primary-derived murine fibroblasts also form multinucleated cells, both in the presence or absence of co-cultured macrophages that increase during long-term culture (5-30 days). In contrast to 3T3 fusion, this primary cell phenomenon is not due to fibroblast fusion, but rather to nuclear division without cytokinesis. That these multinucleated fibroblasts can originate via different mechanisms may influence and distinguish their behaviors in conditions under which they may arise, including various in vitro culture assays, and in certain fibroblastic pathologies such as the foreign body response, fibrosis, cancer and aged tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.