ArticleFree radical biology & medicine2011
Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress.
Article in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo.FASEB bioAdvances · 2019Article
- Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity.Cells · 2019Review
- Characterization and Validation of an "Acute Aerobic Exercise Load" as a Tool to Assess Antioxidative and Anti-inflammatory Nutrition in Healthy Subjects Using a Statistically Integrated Approach in a Comprehensive Clinical Trial.Oxidative medicine and cellular longevity · 2019Article
- Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest.Redox biology · 2016Article
- Article
- A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.Acta crystallographica. Section D, Biological crystallography · 2014Article
- NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.Proceedings of the National Academy of Sciences of the United States of America · 2013 · on this mapArticle
- Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Iron and cancer: more ore to be mined.Nature reviews. Cancer · 2013Review
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Authors and funding
8 authors.
Funding
Abstract
Oxidative stress plays a key role in breast carcinogenesis. To investigate whether normal and malignant breast epithelial cells differ in their responses to oxidative stress, we examined the global gene expression profiles of three cell types, representing cancer progression from a normal to a malignant stage, under oxidative stress. Normal human mammary epithelial cells (HMECs), an immortalized cell line (HMLER-1), and a tumorigenic cell line (HMLER-5) were exposed to increased levels of reactive oxygen species (ROS) by treatment with glucose oxidase. Functional analysis of the metabolic pathways enriched with differentially expressed genes demonstrated that normal and malignant breast epithelial cells diverge substantially in their response to oxidative stress. Whereas normal cells exhibit the up-regulation of antioxidant mechanisms, cancer cells are unresponsive to the ROS insult. However, the gene expression response of normal HMECs under oxidative stress is comparable to that of the malignant cells under normal conditions, indicating that altered redox status is persistent in breast cancer cells, which makes them resistant to increased generation of ROS. We discuss some of the possible adaptation mechanisms of breast cancer cells under persistent oxidative stress that differentiate them from normal mammary epithelial cells as regards the response to acute oxidative stress.
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