ArticleBrain research bulletin2011
Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats.
Article in Brain research bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats.Advances in drug and alcohol research · 2023Article
- Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.Journal of neuroscience research · 2022Article
- Developmental nicotine exposure and masculinization of the rat preoptic area.Neurotoxicology · 2022Article
- Female rats display greater nicotine withdrawal-induced cellular activation of a central portion of the interpeduncular nucleus versus males: A study of Fos immunoreactivity within provisionally assigned interpeduncular subnuclei.Drug and alcohol dependence · 2021Article
- Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors.Frontiers in neuroscience · 2021Review
- Estradiol promotes and progesterone reduces anxiety-like behavior produced by nicotine withdrawal in female rats.Psychoneuroendocrinology · 2020Article
- Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.Neuropharmacology · 2019Article
- Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.Neuropharmacology · 2019Article
- Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal.Addiction biology · 2018Article
- Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review.CNS drugs · 2018Review
- Sexually diergic hypothalamic-pituitary-adrenal axis responses to selective and non-selective muscarinic antagonists prior to cholinergic stimulation by physostigmine in rats.Brain research bulletin · 2018Article
- Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response.Current neuropharmacology · 2018Review
- Sex-dependent effects of nicotine on the developing brain.Journal of neuroscience research · 2017Review
- Sex differences in neurotensin and substance P following nicotine self-administration in rats.Synapse (New York, N.Y.) · 2016Article
- Sex Differences in Animal Models: Focus on Addiction.Pharmacological reviews · 2016Review
- Stress is a principal factor that promotes tobacco use in females.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine.Neurochemical research · 2015Review
- Nicotine withdrawal increases stress-associated genes in the nucleus accumbens of female rats in a hormone-dependent manner.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females.Neuropharmacology · 2014Article
- Behavioral, Biochemical, and Molecular Indices of Stress are Enhanced in Female Versus Male Rats Experiencing Nicotine Withdrawal.Frontiers in psychiatry · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined HPA responses in male and female rats following single doses of NIC, a single-dose of NIC immediately following continuous NIC for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) following continuous NIC infusion for two weeks. Blood sampling occurred before and after MEC and NIC administrations for the determination of ACTH and CORT. In accordance with our previous findings, female ACTH and CORT responses to single-dose NIC were greater than male responses. This sex difference remained after single-dose NIC followed continuous NIC infusion, but HPA responses in both sexes were significantly lower in magnitude and duration than in the single-dose NIC alone groups. Sex differences also were observed following NIC withdrawal by MEC: the HPA responses to pretreatment with MEC were significantly higher in magnitude and duration in the continuous NIC groups than in the single-dose NIC groups. These results demonstrate that HPA responses to NIC are reduced and transient following continuous NIC infusion but are enhanced and sustained following NIC withdrawal by MEC after continuous NIC, suggesting that NIC habituation and withdrawal influence the stress responses in a diergic manner. These findings highlight the importance of sex differences in the effect of NIC on HPA axis activity and stress responsiveness, which may have implications for directing NIC-addiction treatment specifically towards men and women.
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