ArticleBiomaterials2011
The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 148 citations in OpenAlex.
- Recent progress of 3D printed responsive scaffolds for bone repair: A review.Materials today. Bio · 2025Review
- Remote coupling of electrical and mechanical cues by diurnal photothermal irradiation synergistically promotes bone regeneration.Journal of nanobiotechnology · 2024Article
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- 3D Co-Printing and Substrate Geometry Influence the Differentiation of C2C12 Skeletal Myoblasts.Gels (Basel, Switzerland) · 2023Article
- FEM-GAN: A Physics-Supervised Deep Learning Generative Model for Elastic Porous Materials.Materials (Basel, Switzerland) · 2023Article
- Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction.Bioactive materials · 2022Article
- Hybprinting for musculoskeletal tissue engineering.iScience · 2022Review
- A Novel Glucose-Sensitive Scaffold Accelerates Osteogenesis in Diabetic Conditions.BioMed research international · 2022Article
- Effect of 3D Printing Temperature on Bioactivity of Bone Morphogenetic Protein-2 Released from Polymeric Constructs.Annals of biomedical engineering · 2021Article
- Challenges on optimization of 3D-printed bone scaffolds.Biomedical engineering online · 2020Review
- Multimaterial Dual Gradient Three-Dimensional Printing for Osteogenic Differentiation and Spatial Segregation.Tissue engineering. Part A · 2020Article
- TGF-β-induced activation of conjunctival fibroblasts is modulated by FGF-2 and substratum stiffness.PloS one · 2020Article
- Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications.Bioengineering (Basel, Switzerland) · 2019Review
- Three-Dimensional Printing of Tissue Engineering Scaffolds with Horizontal Pore and Composition Gradients.Tissue engineering. Part C, Methods · 2019Article
- MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium.Experimental and therapeutic medicine · 2018Article
- The effect of serum types on Chondrogenic differentiation of adipose-derived stem cells.Biomaterials research · 2018Article
- Extrusion-based 3D printing of poly(propylene fumarate) scaffolds with hydroxyapatite gradients.Journal of biomaterials science. Polymer edition · 2017Article
- Bone biomaterials and interactions with stem cells.Bone research · 2017Review
- 3D bioprinting matrices with controlled pore structure and release function guide in vitro self-organization of sweat gland.Scientific reports · 2016Article
- The potential impact of bone tissue engineering in the clinic.Regenerative medicine · 2016Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Scaffold design parameters, especially physical construction factors such as mechanical stiffness of substrate materials, pore size of 3D porous scaffolds, and channel geometry, are known to influence the osteogenic signal expression and subsequent differentiation of a transplanted cell population. In this study of photocrosslinked poly(propylene fumarate) (PPF) and diethyl fumarate (DEF) scaffolds, the effect of DEF incorporation ratio and pore size on the osteogenic signal expression of rat bone marrow stromal cells (BMSCs) was investigated. Results demonstrated that DEF concentrations and pore sizes that led to increased scaffold mechanical stiffness also upregulated osteogenic signal expression, including bone morphogenic protein-2 (BMP-2), fibroblast growth factors-2 (FGF-2), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), and Runx2 transcriptional factor. Similar scaffold fabrication parameters supported rapid BMSC osteoblastic differentiation, as demonstrated by increased alkaline phosphatase (ALP) and osteocalcin expression. When scaffolds with random architecture, fabricated by porogen leaching, were compared to those with controlled architecture, fabricated by stereolithography (SLA), results showed that SLA scaffolds with the highly permeable and porous channels also have significantly higher expression of FGF-2, TGF-β1, and VEGF. Subsequent ALP expression and osteopontin secretion were also significantly increased in SLA scaffolds. Based upon these results, we conclude that scaffold properties provided by additive manufacturing techniques such as SLA fabrication, particularly increased mechanical stiffness and high permeability, may stimulate dramatic BMSC responses that promote rapid bone tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.