ArticleThe Journal of surgical research2012
Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Near-infrared fluorescence imaging for real-time intraoperative anatomical guidance in minimally invasive surgery: a systematic review of the literature.World journal of surgery · 2015Pooled it
- Prospective trial with optical molecular imaging for percutaneous interventions in focal hepatic lesions.Radiology · 2015Trial
- First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study.Translational research : the journal of laboratory and clinical medicine · 2013Trial
- Trial
- Mechanisms of delayed indocyanine green fluorescence and applications to clinical disease processes.Surgery · 2024Review
- Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green.Sensors (Basel, Switzerland) · 2023Article
- Unexpected detection of a submillimeter early hepatocellular carcinoma focus by intraoperative near-infrared fluorescence imaging-a case report.Annals of translational medicine · 2022Article
- Near-infrared fluorescent clip guided gastrectomy: Report of 2 cases (Case reports).Annals of medicine and surgery (2012) · 2020Article
- The Application of Indocyanine Green Fluorescence Imaging During Robotic Liver Resection: A Case-Matched Study.World journal of surgery · 2019Article
- Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model.Acta cirurgica brasileira · 2019Article
- A new fluorescence imaging technique for visualizing hepatobiliary structures using sodium fluorescein: result of a preclinical study in a rat model.Surgical endoscopy · 2018Article
- Liver tumor boundaries identified intraoperatively using real-time indocyanine green fluorescence imaging.Journal of cancer research and clinical oncology · 2017Article
- Article
- Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy.Oncotarget · 2016Article
- Augmented microscopy: real-time overlay of bright-field and near-infrared fluorescence images.Journal of biomedical optics · 2015Article
- Optimization of the enhanced permeability and retention effect for near-infrared imaging of solid tumors with indocyanine green.American journal of nuclear medicine and molecular imaging · 2015Article
- Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe.Annals of surgical oncology · 2014Article
- Article
- Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field.International journal of nanomedicine · 2014Review
- LED light source for fluorescence endoscopy using quantum dots.... IEEE point-of-care healthcare technologies. PHT (Conference) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNear-infrared (NIR) fluorescence imaging using indocyanine green (ICG) is a promising technique to obtain real-time assessment of the extent and number of colorectal liver metastases during surgery. The current study aims to optimize dosage and timing of ICG administration. MATERIALS AND
methodsLiver tumors were induced in 18 male WAG/Rij rats by subcapsular inoculation of CC531 rat colorectal cancer cells into three distinct liver lobes. Rats were divided in two groups: imaging after 24 and 48 h or 72 and 96 h after intravenous ICG administration. In each time group, rats were allocated to three dose groups: 0.04, 0.08, or 0.16 mg ICG. Intraoperative imaging and ex vivo measurements were performed using the Mini-FLARE imaging system and confirmed by fluorescence microscopy. Fluorescence intensity was quantified using the Mini-FLARE software and the difference between tumor signal and liver signal (tumor-to-liver ratio; TLR) was calculated.
resultsIn all 18 rats, all colorectal liver metastases (n = 34), some as small as 1.2 mm, were identified using ICG and the Mini-FLARE imaging system. Average tumor-to-liver ratio (TLR) over all groups was 3.0 ± 1.2. TLR was significantly higher in the 72 h time group compared with other time points. ICG dose did not significantly influence TLR, but a trend was found favoring the 0.08 mg dose group. Fluorescence microscopy demonstrated a clear fluorescent rim around the tumor.
conclusionsThis study demonstrates that colorectal cancer liver metastases can be clearly identified during surgery using ICG and the Mini-FLARE imaging system, with optimal timing of 72 h post-injection and an optimal dose of 0.08 mg (0.25 mg/kg) ICG. NIR fluorescence imaging has the potential to improve intraoperative detection of micrometastases and, thus, the completeness of resection.
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Registered trials
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