Evidence map›Paper›PMID 21396538›Full record

SynthesisDiagnostic microbiology and infectious disease2011

A meta-analysis of point-of-care laboratory tests in the diagnosis of novel 2009 swine-lineage pandemic influenza A (H1N1).

Steven M Babin, Yu-Hsiang Hsieh, Richard E Rothman, Charlotte A Gaydos

Abstract readMeta-Analysis
In one paragraph

Synthesis in Diagnostic microbiology and infectious disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis.Influenza and other respiratory viruses · 2012
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Prediction of Peaks of Seasonal Influenza in Military Health-Care Data.Biomedical engineering and computational biology · 2016
    Article
  8. Review
  9. Article
  10. Article
  11. Rapid diagnosis of influenza: state of the art.Clinics in laboratory medicine · 2014
    Review
  12. Article
  13. What is the role of newer molecular tests in the management of CAP?Infectious disease clinics of North America · 2013
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven M BabinJohns Hopkins University Applied Physics Laboratory, Laurel, MD 20723, USA. steven.babin@jhuapl.edu
Yu-Hsiang Hsieh
Richard E Rothman
Charlotte A Gaydos

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, JUDITH M. · 2003 to 2013
$91.5M
NIAID NIH HHS U54 AI057168NIAID NIH HHS U54-AI057168-06
6 · The paper itself

Abstract

This paper reviews 14 published studies describing performance characteristics, including sensitivity and specificity, of commercially available rapid, point-of-care (POC) influenza tests in patients affected by an outbreak of a novel swine-related influenza A (H1N1) that was declared a pandemic in 2009. Although these POC tests were not intended to be specific for this pandemic influenza strain, the nonspecialized skills required and the timeliness of results make these POC tests potentially valuable for clinical and public health use. Pooled sensitivity and specificity for the POC tests studied were 68% and 81%, respectively, but published values were not homogeneous with sensitivities and specificities ranging from 10% to 88% and 51% to 100%, respectively. Pooled positive and negative likelihood ratios were 5.94 and 0.42, respectively. These results support current recommendations for use of rapid POC tests when H1N1 is suspected, recognizing that positive results are more reliable than negative results in determining infection, especially when disease prevalence is high.

Indexed as

PandemicsPoint-of-Care SystemsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMiddle Aged

Identifiers

PMID21396538
PMCPMC3058416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.