Evidence map›Paper›PMID 21396508›Full record

ArticleThe American journal of medicine2011

Incidence of cardiovascular events after hospital admission for pneumonia.

Theodore W Perry, Mary Jo V Pugh, Grant W Waterer, Brandy Nakashima, Carlos J Orihuela, Laurel A Copeland, Marcos I Restrepo, Antonio Anzueto, Eric M Mortensen

Abstract read
In one paragraph

Article in The American journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  17. Infection as a Trigger for Cardiovascular Disease.The American journal of medicine · 2020
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  19. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Theodore W PerryVERDICT/South Texas Veterans Health Care System, San Antonio, USA.
Mary Jo V Pugh
Grant W Waterer
Brandy Nakashima
Carlos J Orihuela
Laurel A Copeland
Marcos I Restrepo
Antonio Anzueto
Eric M Mortensen
South Texas Veterans Health Care System · USThe University of Texas Health Science Center at San Antonio · USUniversity of Western Australia · AU

Funding

INSTITUTE FOR INTEGRATION OF MEDICINE & SCIENCE: A PARTNERSHIP TO IMPROVE HEALTHUL1RR025767 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2008 to 2011
$23.8M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR000149 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2012 to 2013
$6.8M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2RR025766 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2008 to 2011
$1.7M
Impact of statins and ACE inhibitors on outcomes for pneumonia and sepsisR01NR010828 · NINR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MORTENSEN, ERIC M. · 2007 to 2009
$947k
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR000118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2012 to 2013
$757k
Statins protect against adverse cardiac events during pneumoniaR21HL108054 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ORIHUELA, CARLOS J · 2011 to 2012
$372k
NCATS NIH HHS KL2 TR000118NCATS NIH HHS UL1 TR000149NCRR NIH HHS KL2 RR025766NCRR NIH HHS KL2RR025766NCRR NIH HHS UL1 RR025767NHLBI NIH HHS R21 HL108054NINR NIH HHS R01 NR010828NINR NIH HHS R01NR010828
6 · The paper itself

Abstract

objectiveSeveral studies have suggested an increased risk of cardiovascular events, primarily acute myocardial infarction, around the time of hospital admission for pneumonia. Therefore, we examined cardiovascular events, including myocardial infarction, congestive heart failure, unstable angina, stroke, and serious cardiac arrhythmias, within 90 days after hospitalization for pneumonia.

methodsBy using data from the administrative databases of the Department of Veterans Affairs, we examined a cohort of subjects hospitalized with pneumonia between October 2001 and September 2007. Subjects were at least 65 years of age. We examined the incidence of myocardial infarction, congestive heart failure, cardiac arrhythmias, unstable angina, and stroke by International Classification of Diseases, Ninth Revision codes, excluding those with a diagnosis before the admission for pneumonia.

resultsThe cohort comprised 50,119 subjects with a mean age of 77.5 years (standard deviation 6.7 years), 98% of whom were male. The 90-day incidence of cardiovascular events was 1.5% for myocardial infarction, 10.2% for congestive heart failure, 9.5% for arrhythmia, 0.8% for unstable angina, and 0.2% for stroke. The majority of events occurred during the hospitalization for pneumonia.

conclusionA clinically important number of subjects in this cohort had a cardiovascular event within 90 days of hospital admission, suggesting that such events may have an important role in post-pneumonia mortality. Additional research is needed to determine whether interventions may reduce the number of cardiovascular events after pneumonia.

Indexed as

HospitalizationAgedAged, 80 and overAngina, UnstableArrhythmias, CardiacBiomarkersCardiovascular DiseasesCohort StudiesComorbidityConfounding Factors, EpidemiologicDatabases, FactualFemaleHeart FailureHumansIncidenceInpatientsBiomarkers

Identifiers

PMID21396508
PMCPMC3061467
OpenAlexW2115109558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.