SynthesisOsteoarthritis and cartilage2011
Responsiveness to change and reliability of measurement of radiographic joint space width in osteoarthritis of the knee: a systematic review.
Synthesis in Osteoarthritis and cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients - ZAP2.BMC musculoskeletal disorders · 2018Trial
- The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes.Osteoarthritis and cartilage · 2015Trial
- Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis: study protocol for a randomized controlled trial.BMC musculoskeletal disorders · 2013Trial
- Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study.BMC musculoskeletal disorders · 2013Trial
- Changes in bone marrow lesions in response to weight-loss in obese knee osteoarthritis patients: a prospective cohort study.BMC musculoskeletal disorders · 2013Trial
- Adding triamcinolone improves viscosupplementation: a randomized clinical trial.Clinical orthopaedics and related research · 2013Trial
- Lateral wedge insoles for medial knee osteoarthritis: 12 month randomised controlled trial.BMJ (Clinical research ed.) · 2011Trial
- Diffusion Tensor Imaging of Knee Cartilage for Detection of Early Osteoarthritis and Prediction of Radiographic Progression.Journal of magnetic resonance imaging : JMRI · 2026Article
- The impact of knee positioning on joint space width change: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2026Article
- Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review.Osteoarthritis and cartilage open · 2026Review
- The role of radiography and MRI as screening tools and outcome measures in clinical trials of knee osteoarthritis: a perspective on the current status and outlook.Therapeutic advances in musculoskeletal disease · 2026Review
- Ultrasound Phenotype-Based Approach to Treatment Choice in Osteoarthritis.Life (Basel, Switzerland) · 2025Article
- Single Stance Radiography of the Knee Joint - A Novel Approach to Assess the Degree of Knee Osteoarthritis.Journal of orthopaedic case reports · 2024Article
- Nanoarchitectonics of Injectable Biomimetic Conjugates for Cartilage Protection and Therapy Based on Degenerative Osteoarthritis Progression.Biomaterials research · 2024Article
- Deep learning applications in osteoarthritis imaging.Skeletal radiology · 2023Review
- Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D JSW on weight-bearing CT vs 2D JSW on radiographs in the MOST study.Osteoarthritis and cartilage · 2023Article
- Do Weight-Bearing Knee Digital Radiographs Help to Track the Severity of OA?Indian journal of orthopaedics · 2022Article
- Radiologists and Clinical Trials: Part 2: Practical Statistical Methods for Understanding and Monitoring Independent Reader Performance.Therapeutic innovation & regulatory science · 2021Review
- A four-genes based diagnostic signature for osteoarthritis.Rheumatology international · 2021Article
- Low Rates of Radiographic Knee Osteoarthritis 5 Years After ACL Reconstruction or Rehabilitation Alone: The Delaware-Oslo ACL Cohort Study.Orthopaedic journal of sports medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe goal of this systematic review was to report the responsiveness to change and reliability of conventional radiographic joint space width (JSW) measurement.
methodWe searched the PubMed and Embase databases using the following search criteria: [osteoarthritis (OA) (MeSH)] AND (knee) AND (X-ray OR radiography OR diagnostic imaging OR radiology OR disease progression) AND (joint space OR JSW or disease progression). We assessed responsiveness by calculating the standardized response mean (SRM). We assessed reliability using intra- and inter-reader intra-class correlation (ICC) and coefficient of variation (CV). Random-effects models were used to pool results from multiple studies. Results were stratified by study duration, design, techniques of obtaining radiographs, and measurement method.
resultsWe identified 998 articles using the search terms. Of these, 32 articles (43 estimates) reported data on responsiveness of JSW measurement and 24 (50 estimates) articles reported data on measures of reliability. The overall pooled SRM was 0.33 [95% confidence interval (CI): 0.26, 0.41]. Responsiveness of change in JSW measurement was improved substantially in studies of greater than 2 years duration (0.57). Further stratifying this result in studies of greater than 2 years duration, radiographs obtained with the knee in a flexed position yielded an SRM of 0.71. Pooled intra-reader ICC was estimated at 0.97 (95% CI: 0.92, 1.00) and the intra-reader CV estimated at 3.0 (95% CI: 2.0, 4.0). Pooled inter-reader ICC was estimated at 0.93 (95% CI: 0.86, 0.99) and the inter-reader CV estimated at 3.4% (95% CI: 1.3%, 5.5%).
conclusionsMeasurement of JSW obtained from radiographs in persons with knee is reliable. These data will be useful to clinicians who are planning RCTs where the change in minimum JSW is the outcome of interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.