SynthesisOsteoarthritis and cartilage2011
Systematic review of the concurrent and predictive validity of MRI biomarkers in OA.
Synthesis in Osteoarthritis and cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- Molecular cartilage pathology following anterior cruciate ligament reconstruction: a systematic review of MRI studies.Frontiers in surgery · 2026Pooled it
- Medical imaging for plantar heel pain: a systematic review and meta-analysis.Journal of foot and ankle research · 2022Pooled it
- A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis.Arthritis research & therapy · 2015Pooled it
- Estimation of the Effect of Body Weight on the Development of Osteoarthritis Based on Cumulative Stresses in Cartilage: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2018Trial
- The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes.Osteoarthritis and cartilage · 2015Trial
- Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial.Arthritis research & therapy · 2015Trial
- Effects of a progressive aquatic resistance exercise program on the biochemical composition and morphology of cartilage in women with mild knee osteoarthritis: protocol for a randomised controlled trial.BMC musculoskeletal disorders · 2013Trial
- Adding triamcinolone improves viscosupplementation: a randomized clinical trial.Clinical orthopaedics and related research · 2013Trial
- The emerging role of subchondral bone homeostasis in osteoarthritis.Journal of orthopaedic translation · 2026Review
- Neurophysiological, Radiological, and Molecular Biomarkers of Pain-Related Conditions: An Umbrella Review.Journal of clinical medicine · 2026Review
- Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment.Diagnostics (Basel, Switzerland) · 2025Review
- Contralateral knee osteoarthritis severity relates to magnetic resonance imaging findings in knees with and without osteoarthritis: Data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2025Article
- 3D-MRI analysis of cartilage thickness changes after PRP injection in medial knee osteoarthritis: A preliminary report.PloS one · 2025Article
- The Condition of the Meniscus and Cartilage of the Injured Knee on Preoperative Magnetic Resonance Imaging Is a Prognostic Factor Affecting Postoperative Outcomes Following Knee Cartilage Restoration Surgery.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Approaches to optimize analyses of multidimensional ordinal MRI data in osteoarthritis research: A perspective.Osteoarthritis and cartilage open · 2024Article
- Prediction of total knee replacement using deep learning analysis of knee MRI.Scientific reports · 2023Article
- Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis.Journal of clinical medicine · 2023Article
- [Research progress of failure and revision of unicompartmental knee arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Association Between Power Doppler Ultrasound Signals and Chronic Pain After Total Knee Arthroplasty: A Cross-Sectional Explorative Study.Journal of pain research · 2023Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveTo summarize literature on the concurrent and predictive validity of MRI-based measures of osteoarthritis (OA) structural change.
methodsAn online literature search was conducted of the OVID, EMBASE, CINAHL, PsychInfo and Cochrane databases of articles published up to the time of the search, April 2009. 1338 abstracts obtained with this search were preliminarily screened for relevance by two reviewers. Of these, 243 were selected for data extraction for this analysis on validity as well as separate reviews on discriminate validity and diagnostic performance. Of these 142 manuscripts included data pertinent to concurrent validity and 61 manuscripts for the predictive validity review. For this analysis we extracted data on criterion (concurrent and predictive) validity from both longitudinal and cross-sectional studies for all synovial joint tissues as it relates to MRI measurement in OA.
resultsConcurrent validity of MRI in OA has been examined compared to symptoms, radiography, histology/pathology, arthroscopy, CT, and alignment. The relation of bone marrow lesions, synovitis and effusion to pain was moderate to strong. There was a weak or no relation of cartilage morphology or meniscal tears to pain. The relation of cartilage morphology to radiographic OA and radiographic joint space was inconsistent. There was a higher frequency of meniscal tears, synovitis and other features in persons with radiographic OA. The relation of cartilage to other constructs including histology and arthroscopy was stronger. Predictive validity of MRI in OA has been examined for ability to predict total knee replacement (TKR), change in symptoms, radiographic progression as well as MRI progression. Quantitative cartilage volume change and presence of cartilage defects or bone marrow lesions are potential predictors of TKR.
conclusionMRI has inherent strengths and unique advantages in its ability to visualize multiple individual tissue pathologies relating to pain and also predict clinical outcome. The complex disease of OA which involves an array of tissue abnormalities is best imaged using this imaging tool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.