ReviewNeurobiology of disease2012
The first decade and beyond of transcriptional profiling in schizophrenia.
Review in Neurobiology of disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of sex differences in gene expression in schizophrenia.BMC systems biology · 2016Pooled it
- Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls.BMC neuroscience · 2013Pooled it
- Network-based drug repurposing for schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder.Translational psychiatry · 2019Article
- Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches.Molecular neuropsychiatry · 2019Review
- Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder.Molecular neuropsychiatry · 2019Review
- CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Article
- Subchronic olanzapine exposure leads to increased expression of myelination-related genes in rat fronto-medial cortex.Translational psychiatry · 2017Article
- Theranostic Biomarkers for Schizophrenia.International journal of molecular sciences · 2017Review
- Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders.Microarrays (Basel, Switzerland) · 2016Article
- Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014.Psychiatric genetics · 2016Article
- Molecular substrates of schizophrenia: homeostatic signaling to connectivity.Molecular psychiatry · 2016Review
- Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia.Schizophrenia research · 2015Article
- Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls.Psychiatry research · 2015Article
- The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.Annals of the New York Academy of Sciences · 2015Review
- Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.Bipolar disorders · 2014Article
- Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research.Biological psychiatry · 2014Review
- Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness.Translational psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Gene expression changes in brains of individuals with schizophrenia (SZ) have been hypothesized to reflect possible pathways related to pathophysiology and/or medication. Other factors having robust effects on gene expression profiling in brain and possibly influence the schizophrenia transcriptome such as age and pH are examined. Pathways of curated gene expression or gene correlation networks reported in SZ (white matter, apoptosis, neurogenesis, synaptic plasticity, glutamatergic and GABAergic neurotransmission, immune and stress-response, mitochondrial, and neurodevelopment) are not unique to SZ and have been associated with other psychiatric disorders. Suggestions going forward to improve the next decade of profiling: consider multiple brain regions that are carefully dissected, release large datasets from multiple brain regions in controls to better understand neurocircuitry, integrate genetics and gene expression, measure expression variants on genome wide level, peripheral biomarker studies, and analyze the transcriptome across a developmental series of brains. Gene expression, while an important feature of the genomic landscape, requires further systems biology to advance from control brains to a more precise definition of the schizophrenia interactome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.