Evidence map›Paper›PMID 21395967›Full record

ArticleAging cell2011

Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.

Richard A Miller, David Dolan, Melissa Han, William Kohler, Jochen Schacht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Richard A MillerDepartment of Pathology and Geriatrics Center, University of Michigan School of Medicine, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu
David Dolan
Melissa Han
William Kohler
Jochen Schacht
University of Michigan · USMichigan Medicine · US

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Research DevelopmentP30AG013283 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, RICHARD A · 1995 to 2014
$12.3M
STRESS PATHWAYS IN THE AGING COCHLEAP01AG025164 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHACHT, JOCHEN · 2005 to 2009
$6.6M
NIA NIH HHS AG013283NIA NIH HHS AG024824NIA NIH HHS AG025164NIA NIH HHS P01 AG025164NIA NIH HHS P30 AG013283NIA NIH HHS P30 AG024824
6 · The paper itself

Abstract

Those mice whose skin-derived primary fibroblast cell lines resist lethal injury induced by hydrogen peroxide or UV light show lower age-related decline in hearing. Skin cell lines may provide an easily accessible surrogate index of intrinsic stress resistance that varies among individuals and influences the pace of neurosensory decline in aging mice.

Indexed as

AgingAnimalsBiomarkersCell LineFibroblastsHearing LossHydrogen PeroxideMiceMice, Inbred StrainsOxidantsOxidative StressSkinUltraviolet RaysBiomarkersHydrogen PeroxideOxidants

Identifiers

PMID21395967
PMCPMC3079202
OpenAlexW1895304640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.