ReviewThe European journal of neuroscience2011
Neurotransmitters couple brain activity to subventricular zone neurogenesis.
Review in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review.Frontiers in cellular neuroscience · 2020Pooled it
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM-SHAP ClassificationCNS neuroscience & therapeutics · 2026Article
- Review
- Regulation of neural stem cells by innervating neurons.Journal of neurochemistry · 2025Review
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Adult neurogenesis: a real hope or a delusion?Neural regeneration research · 2024Review
- Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation.Scientific reports · 2023Article
- Cortical regulation of neurogenesis and cell proliferation in the ventral subventricular zone.Cell reports · 2023Article
- Neural Progenitor Cells and the Hypothalamus.Cells · 2023Review
- Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCs.Stem cell reviews and reports · 2023Article
- Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation.Stem cell reviews and reports · 2022Review
- The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling.Frontiers in oncology · 2022Review
- A potential role for somatostatin signaling in regulating retinal neurogenesis.Scientific reports · 2021Article
- A preview of selected articles.Stem cells translational medicine · 2021Article
- Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury.Frontiers in neurology · 2020Review
- Article
- GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.American journal of human genetics · 2019Article
- The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.Cellular and molecular life sciences : CMLS · 2019Review
- Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages.Cell reports · 2019Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adult neurogenesis occurs in two privileged microenvironments, the hippocampal subgranular zone of the dentate gyrus and the subventricular zone (SVZ) along the lateral ventricle. This review focuses on accumulating evidence suggesting that the activity of specific brain regions or bodily states influences SVZ cell proliferation and neurogenesis. Neuromodulators such as dopamine and serotonin have been shown to have long-range effects through neuronal projections into the SVZ. Local γ-aminobutyric acid and glutamate signaling have demonstrated effects on SVZ proliferation and neurogenesis, but an extra-niche source of these neurotransmitters remains to be explored and options will be discussed. There is also accumulating evidence that diseases and bodily states such as Alzheimer's disease, seizures, sleep and pregnancy influence SVZ cell proliferation. With such complex behavior and environmentally-driven factors that control subregion-specific activity, it will become necessary to account for overlapping roles of multiple neurotransmitter systems on neurogenesis when developing cell therapies or drug treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.