Evidence map›Paper›PMID 21395378›Full record

ReviewImmunotherapy2011

Cancer radioimmunotherapy.

Robert M Sharkey, David M Goldenberg

Abstract readReview
In one paragraph

Review in Immunotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 136 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Multidrug resistantCurrent research in microbial sciences · 2025
    Review
  9. Article
  10. Antibodies (Basel, Switzerland) · 2024
    Article
  11. Article
  12. Article
  13. Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  14. Intricacies in the Preparation of Patient Doses of [Molecular imaging and biology · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Combination ofScientific reports · 2021
    Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert M SharkeyGarden State Cancer Center, Belleville, NJ 07109, USA. rmsharkey@gscancer.org
David M Goldenberg
Center for Molecular Medicine and Immunology · US

Funding

Targeted Therapy of B-cell MalignanciesP01CA103985 · NCI · CTR FOR MOLECULAR MEDICINE/IMMUNOLOGY · PI GOLDENBERG, DAVID M · 2005 to 2009
$7.0M
Bispecific Antibody Pretargeting for TherapyR01CA107088 · NCI · CTR FOR MOLECULAR MEDICINE/IMMUNOLOGY · PI SHARKEY, ROBERT M · 2006 to 2009
$1.7M
NCI NIH HHS P01 CA103985NCI NIH HHS R01 CA107088
6 · The paper itself

Abstract

Targeting of radionuclides with antibodies, or radioimmunotherapy, has been an active field of research spanning nearly 50 years, evolving with advancing technologies in molecular biology and chemistry, and with many important preclinical and clinical studies illustrating the benefits, but also the challenges, which all forms of targeted therapies face. There are currently two radiolabeled antibodies approved for the treatment of non-Hodgkin lymphoma, but radioimmunotherapy of solid tumors remains a challenge. Novel antibody constructs, focusing on treatment of localized and minimal disease, and pretargeting are all promising new approaches that are currently under investigation.

Indexed as

Drug Delivery SystemsNeoplasmsRadioimmunotherapyAnimalsAntibodies, BispecificAntibodies, MonoclonalHumansLymphoma, Non-HodgkinRadioisotopesAntibodies, BispecificAntibodies, MonoclonalRadioisotopes

Identifiers

PMID21395378
PMCPMC3123828
OpenAlexW4211120843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.