Evidence map›Paper›PMID 21395365›Full record

ReviewSports medicine (Auckland, N.Z.)2011

L-Arginine as a potential ergogenic aid in healthy subjects.

Thiago S Álvares, Cláudia M Meirelles, Yagesh N Bhambhani, Vânia M F Paschoalin, Paulo S C Gomes

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03827005 (The Acute Effects of L-arginine Supplementation on Flow-mediated Dilation After Resistance Exercise to Fatigue), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03827005 nacompletednot on this mapstarted 2016, after this paper: background citation

The Acute Effects of L-arginine Supplementation on Flow-mediated Dilation After Resistance Exercise to Fatigue

TypeinterventionalSponsorNorth Dakota State UniversityRan2016 to 2017Enrolled30ConditionsHealthy AdultArmsL-arginine, Placebo
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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  17. Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study.Journal of nutrition in gerontology and geriatrics
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Thiago S ÁlvaresLaboratory Crossbridges, Center for Interdisciplinary Research in Health, Department of Physical Education, Universidade Gama Filho, Rio de Janeiro, Brazil.
Cláudia M Meirelles
Yagesh N Bhambhani
Vânia M F Paschoalin
Paulo S C Gomes
University Gama Filho · BRUniversidade Federal do Rio de Janeiro · BRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary supplements containing L-arginine, a semi-essential amino acid, are one of the latest ergogenic aids intended to enhance strength, power and muscle recovery associated with both aerobic and resistance exercise. L-arginine is claimed to promote vasodilation by increasing nitric oxide (NO) production in the active muscle during exercise, improving strength, power and muscular recovery through increased substrate utilization and metabolite removal, such as lactate and ammonia. Research on L-arginine has recently tested this hypothesis, under the assumption that it may be the active compound associated with the vasodilator effects of NO. There were only five acute studies retrieved from the literature that evaluated exercise performance after L-arginine supplementation, three of which reported significant improvements. Regarding studies on chronic effects, eight studies were encountered: four reported enhancements in exercise performance, whilst four reports showed no changes. Whether these improvements in exercise performance - regardless of the aerobic or anaerobic nature of the exercise - can be associated with increases in NO production, has yet to be demonstrated in future studies. Low oral doses (≤20 g) are well tolerated and clinical side effects are rare in healthy subjects. In summary, it is still premature to recommend dietary supplements containing L-arginine as an ergogenic aid for healthy physically active subjects.

Indexed as

Dietary SupplementsArginineAthletic PerformanceEnergy MetabolismExerciseHumansMuscle StrengthNitric OxidePhysical EndurancePhysical FitnessResistance TrainingVasodilationArginineNitric Oxide

Identifiers

PMID21395365
OpenAlexW1988600687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.