ArticleMagnetic resonance in medicine2011
Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors.
Article in Magnetic resonance in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02021526 (Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency), which is not on this map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency
Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Simultaneous Detection of GABA and Glycine Using MEGA-PRESS With TE Optimization at 3T.Magnetic resonance in medicine · 2026Article
- A multiparametric perspective on C6 and F98 cell lines in orthotopic rat models for glioblastoma research.Scientific reports · 2025Article
- Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.Frontiers in oncology · 2025Article
- Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas.NMR in biomedicine · 2025Article
- Neurochemical dynamics during two hypnotic states evidenced by magnetic resonance spectroscopy.Scientific reports · 2024Article
- Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients.Journal of neuro-oncology · 2024Article
- Ketogenic diet as a glycine lowering therapy in nonketotic hyperglycinemia and impact on brain glycine levels.Orphanet journal of rare diseases · 2022Article
- Magnetic resonance spectroscopy for the study of cns malignancies.Progress in nuclear magnetic resonance spectroscopy · 2021Article
- GlyCEST: Magnetic Resonance Imaging of Glycine-Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice.Contrast media & molecular imaging · 2021Article
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.Neuro-oncology · 2020Article
- Elevated glycine detected on in vivo magnetic resonance spectroscopy in a breast cancer patient: case report and literature review.BJR case reports · 2020Article
- The Role of Imaging Biomarkers Derived From Advanced Imaging and Radiomics in the Management of Brain Tumors.Frontiers in oncology · 2020Article
- Short-acquisition-time JPRESS and its application to paediatric brain tumours.Magma (New York, N.Y.) · 2019Article
- Glycine: a non-invasive imaging biomarker to aid magnetic resonance spectroscopy in the prediction of survival in paediatric brain tumours.Oncotarget · 2018Article
- Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM.BMC cancer · 2018Article
- Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.Journal of neuro-oncology · 2018Article
- Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.NMR in biomedicine · 2017Article
- EditedMagnetic resonance in medicine · 2017Review
- Effects of tissue susceptibility on brain temperature mapping.NeuroImage · 2017Article
- Functional assessment of glioma pathogenesis by in vivo multi-parametric magnetic resonance imaging and in vitro analyses.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Glycine is a key metabolic intermediate required for the synthesis of proteins, nucleic acids, and other molecules, and its detection in cancer could, therefore, provide biologically relevant information about the growth of the tumor. Here, we report measurement of glycine in human brain and gliomas by an optimized point-resolved spectroscopy sequence at 3 T. Echo time dependence of the major obstacle, myo-inositol (mI) multiplet, was investigated with numerical simulations, incorporating the 3D volume localization. The simulations indicated that a subecho pair (TE(1) , TE(2) ) = (60, 100) ms permits detection of both glycine and mI with optimum selectivity. In vivo validation of the optimized point-resolved spectroscopy was conducted on the right parietal cortex of five healthy volunteers. Metabolite signals estimated from LC Model were normalized with respect to the brain water signal, and the concentrations were evaluated assuming the total creatine concentration at 8 mM. The glycine concentration was estimated as 0.6 ± 0.1 mM (mean ± SD, n = 5), with a mean Cramér-Rao lower bound of 9 ± 1%. The point-resolved spectroscopy sequence was applied to measure the glycine levels in patients with glioblastoma multiforme. Metabolite concentrations were obtained using the water signal from the tumor mass. The study revealed that a subset of human gliomas contains glycine levels elevated 1.5-8 fold relative to normal.
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Registered trials
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