ArticlePloS one2011
Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Network-Based Analysis of OMICs Data to Understand the HIV-Host Interaction.Frontiers in microbiology · 2020Review
- Large-Scale "OMICS" Studies to Explore the Physiopatholgy of HIV-1 Infection.Frontiers in genetics · 2019Review
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- Genetic differences among ethnic groups.BMC genomics · 2015Article
- Discriminating between deleterious and neutral non-frameshifting indels based on protein interaction networks and hybrid properties.Molecular genetics and genomics : MGG · 2015Article
- Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs.PloS one · 2015Article
- Identifying the subfamilies of voltage-gated potassium channels using feature selection technique.International journal of molecular sciences · 2014Article
- Identification of Influenza A/H7N9 virus infection-related human genes based on shortest paths in a virus-human protein interaction network.BioMed research international · 2014Article
- Article
- Large-scale protein-protein interactions detection by integrating big biosensing data with computational model.BioMed research international · 2014Article
- Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes.BMC medical genomics · 2013Article
- Article
- Signal propagation in protein interaction network during colorectal cancer progression.BioMed research international · 2013Article
- Biomedical informatics for computer-aided decision support systems: a survey.TheScientificWorldJournal · 2013Review
- Dysfunctions associated with methylation, microRNA expression and gene expression in lung cancer.PloS one · 2012Article
- Predicting transcriptional activity of multiple site p53 mutants based on hybrid properties.PloS one · 2011Article
- Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 resistance is important for the development of HIV-1 vaccines and Acquired Immune Deficiency Syndrome (AIDS) therapies. In this study, we analyzed the gene expression profiles of CD4+ T cells from HIV-1-resistant individuals and HIV-susceptible individuals. One hundred eighty-five discriminative HIV-1 resistance genes were identified using the Minimum Redundancy-Maximum Relevance (mRMR) and Incremental Feature Selection (IFS) methods. The virus protein target enrichment analysis of the 185 HIV-1 resistance genes suggested that the HIV-1 protein nef might play an important role in HIV-1 infection. Moreover, we identified 29 infection information exchanger genes from the 185 HIV-1 resistance genes based on a virus-host interaction network analysis. The infection information exchanger genes are located on the shortest paths between virus-targeted proteins and are important for the coordination of virus infection. These proteins may be useful targets for AIDS prevention or therapy, as intervention in these pathways could disrupt communication with virus-targeted proteins and HIV-1 infection.
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