Evidence map›Paper›PMID 21394176›Full record

ReviewNature reviews. Urology2011

Biomarker research in prostate cancer--towards utility, not futility.

Sheng Fei Oon, Stephen R Pennington, John M Fitzpatrick, R William G Watson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Targeting Fibronectin for Cancer Imaging and Therapy.Journal of materials chemistry. B · 2017
    Article
  5. Prostate Cancer Detection Using Composite Impedance Metric.IEEE transactions on medical imaging · 2016
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Evaluation of prediction models for the staging of prostate cancer.BMC medical informatics and decision making · 2013
    Article
  11. Current status of biomarkers for prostate cancer.International journal of molecular sciences · 2013
    Review
  12. Review
  13. Article
  14. Patented prostate cancer biomarkers.Nature reviews. Urology · 2012
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sheng Fei OonUCD School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. sheng-fei.oon@ucd.ie
Stephen R Pennington
John M Fitzpatrick
R William G Watson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification of an appropriate clinical question is critical for any biomarker project. Despite rapid advances in technology, few biomarkers have been forthcoming for prostate cancer. This could be because the clinical questions under investigation have not actually originated from clinical practice. These clinical questions are difficult to identify in the complex and heterogeneous pathogenesis of prostate cancer. In this Review, we have developed a prostate cancer 'roadmap' to identify the aspects of prostate cancer that may be amenable to biomarker discovery and serve as a guide for future projects in prostate cancer biomarker research.

Indexed as

Medical FutilityAnimalsBiomarkersBiomarkers, TumorForecastingHumansMaleNeoplasm StagingProstatic NeoplasmsBiomarkersBiomarkers, Tumor

Identifiers

PMID21394176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.