ReviewCell death and differentiation2011
The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?
Review in Cell death and differentiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptomic profiles of susceptibility and resilience to stress in the amygdala and hippocampus of male rats.Neurobiology of stress · 2025Article
- FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.Scientific reports · 2025Article
- Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation.Molecular cell · 2024Article
- Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.Cell death and differentiation · 2024Article
- The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.Frontiers in immunology · 2024Article
- Upregulation of ZMAT3 is Associated with the Poor Prognosis of Breast Cancer.International journal of general medicine · 2024Article
- Increased cell senescence in human metabolic disorders.The Journal of clinical investigation · 2023Review
- Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis.Cell death & disease · 2020Article
- Network hub-node prioritization of gene regulation with intra-network association.BMC bioinformatics · 2020Article
- WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.Nucleic acids research · 2017Article
- Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness.International journal of molecular sciences · 2016Review
- Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation.Scientific reports · 2016Article
- Article
- Uncovering RNA binding proteins associated with age and gender during liver maturation.Scientific reports · 2015Article
- Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.Oncogene · 2014Article
- Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.PloS one · 2014Article
- Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta.PloS one · 2013Article
- p63 the guardian of human reproduction.Cell cycle (Georgetown, Tex.) · 2012Review
- Article
- Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.Free radical biology & medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wig-1 is a transcriptional target of the tumor suppressor p53 and encodes an unusual zinc-finger protein involved in post-transcriptional gene regulation. Wig-1 is expressed in all cell types investigated so far, with the highest levels in the brain, and is enriched in stem cells as compared with more differentiated cells of the same lineage. Wig-1 binds to both long double-stranded (ds) RNA and short microRNA-like dsRNA. We have shown that Wig-1 acts in a positive feedback loop that stabilizes p53 mRNA through an AU-rich element (ARE) in the p53 3'untranslated region. Our preliminary data indicate a more general effect of Wig-1 on ARE-containing mRNA. Here we shall summarize current knowledge about Wig-1 and discuss possible implications on p53 function and other cellular processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.