ArticleActa crystallographica. Section F, Structural biology and crystallization communications2011
Neutron fibre diffraction studies of amyloid using H2O/D2O isotopic replacement.
Article in Acta crystallographica. Section F, Structural biology and crystallization communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Water in crystalline fibers of dihydrate β-chitin results in unexpected absence of intramolecular hydrogen bonding.PloS one · 2012Article
- Preliminary neutron crystallographic study of human transthyretin.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
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Authors and funding
8 authors at 4 institutions in 4 countries.
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Abstract
The first neutron fibre diffraction studies of an amyloid system are presented. The techniques used to prepare the large samples needed are described, as well as the procedures used to isotopically replace H2O in the sample by D2O. The results demonstrate the feasibility of this type of approach for the pursuit of novel structural analyses that will strongly complement X-ray fibre diffraction studies and probe aspects of amyloid structure that to date have remained obscure. The approach is demonstrated using an amyloid form of the peptide NSGAITIG, but is equally applicable for the study of other systems such as Alzheimer's Aβ peptide.
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