ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Potential premalignant status of gastric portion excluded after Roux en-Y gastric bypass in obese women: A pilot study.Scientific reports · 2019Trial
- Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.Medical review (2021) · 2026Review
- Spatial transcriptomic analysis of foveolar-type gastric adenoma with raspberry-like appearance.Virchows Archiv : an international journal of pathology · 2026Article
- Deoxynivalenol modulated mucin expression and proinflammatory cytokine production, affecting susceptibility to enteroinvasive Escherichia coli infection in intestinal epithelial cells.Journal of food science · 2025Article
- Mucus and mucin: changes in the mucus barrier in disease states.Tissue barriers · 2025Review
- The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation.Seminars in immunopathology · 2024Review
- MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C.Journal of cell science · 2024Article
- Transcriptional Signatures That Define Ulcerative Colitis in Remission.Inflammatory bowel diseases · 2021Article
- Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane.The Biochemical journal · 2019Article
- The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles.Materials (Basel, Switzerland) · 2018Article
- Study of mucin turnover in the small intestine by in vivo labeling.Scientific reports · 2018Article
- The effects of fermentation products of prebiotic fibres on gut barrier and immune functions in vitro.PeerJ · 2018Article
- Molecular Pathways: Mucins and Drug Delivery in Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Leucine increases mucin 2 and occludin production in LS174T cells partially via PI3K-Akt-mTOR pathway.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2016Article
- Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.Oncogene · 2016Article
- Enteric Pathogens Exploit the Microbiota-generated Nutritional Environment of the Gut.Microbiology spectrum · 2015Article
- Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells.Genes & nutrition · 2015Article
- Core 2 mucin-type O-glycan inhibits EPEC or EHEC O157:H7 invasion into HT-29 epithelial cells.Gut pathogens · 2015Article
- RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The membrane-bound mucin MUC17 (mouse homolog Muc3) is highly expressed on the apical surface of intestinal epithelia and is thought to play a role in epithelial restitution and protection. Therefore, we hypothesized that MUC17 has a role in protection of the intestinal mucosa against luminal pathogens. Human intestinal cell lines were transfected by electroporation (Caco-2 and HT 29/19A) and by retroviral expression vector (LS174T, a cell line with high levels of MUC17 expression) using MUC17 siRNA. Transepithelial electrical resistance, permeability, tight-junction protein expression, adhesion, and invasion in response to enteroinvasive Escherichia coli (EIEC) were measured in all cell lines. In some experiments, the effect of the addition of exogenous purified crude mucin or recombinant Muc3 cysteine-rich domain protein (Muc3 CRD1-L-CRD2) as preventative or protective treatment was tested. Reduction of endogenous MUC17 is associated with increased permeability, inducible nitric oxide synthase and cyclooxygenase 2 induction, and enhanced bacterial invasion in response to EIEC exposure. Bacterial adhesion is not affected. Exogenous mucin (Muc3) and recombinant Muc3CRD treatment had a small but significant effect in attenuating the effects of EIEC infection. In conclusion, these data suggest that both native and exogenous MUC17 play a role in attachment and invasion of EIEC in colonic cell lines and in maintaining epithelial barrier function.
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