ArticleMolecular genetics and metabolism2011
Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.
Article in Molecular genetics and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- CNDP1 and Diabetic Kidney Disease: From Genetic Susceptibility to Therapeutic Targeting.Genes · 2026Review
- Integrated transcriptomic and metabolomic analysis of goose epididymis reveals molecular markers associated with sperm mobility.Poultry science · 2025Article
- Low Plasma Carnosinase-1 Activity in Patients with Left Ventricular Systolic Dysfunction: Implications for Carnosine Therapy in Heart Failure.International journal of molecular sciences · 2025Article
- Serum Carnosinase 1 Is Not Associated with Insulin Resistance or Glucose Metabolism in a Type 1 Diabetes Cohort.Biomedicines · 2025Article
- Mass-spectrometry-based quantitative proteomic analysis reveals that methylglyoxal and carnosine influence oxidative stress and RNA-processing associated proteins in renal proximal tubule epithelial cells.Molecular biology reports · 2025Article
- Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms.Proteomes · 2024Article
- Profound perturbations are found in the proteome and metabolome in children with obesity after weight loss intervention.Heliyon · 2024Article
- Article
- Association Between Serum Carnosinase Concentration and Activity and Renal Function Impairment in a Type-2 Diabetes Cohort.Frontiers in pharmacology · 2022Article
- Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients.Amino acids · 2021Article
- Article
- Genetic and Epigenetic Studies in Diabetic Kidney Disease.Frontiers in genetics · 2019Review
- TheJournal of diabetes research · 2017Article
- The (CTG)The Indian journal of medical research · 2016Article
- Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.The Korean journal of internal medicine · 2015Article
- Carnosinases, their substrates and diseases.Molecules (Basel, Switzerland) · 2014Review
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
CNDP1 is located on 18q22.3, where linkage with diabetic nephropathy has been observed in several populations, including Pima Indians. However, evidence for association between CNDP1 alleles and diabetic nephropathy is equivocal and population-dependent. This study investigated CNDP1 as a candidate for diabetic kidney disease in Pima Indians. Nineteen tag single nucleotide polymorphisms spanning the CNDP1 locus were selected using genotype data from Chinese individuals in the HapMap resource along with 2 variants previously associated with diabetic nephropathy. All variants were genotyped in 3 different samples including a diabetic end-stage renal disease (ESRD) case-control study, a family-based study of diabetic individuals who participated in the linkage study for nephropathy, and a cohort of diabetic individuals in whom longitudinal measures of glomerular filtration rates (GFR) were performed. There was no statistically significant evidence for association with diabetic ESRD. However, nominal evidence for association was found in the family study, where markers rs12957330 (Odds ratio [OR]=0.29 per copy of G allele; p=0.04) and rs17817077 (OR=0.46 per copy of G allele; p=0.05) were associated with diabetic nephropathy. In addition, markers rs12964454, rs7244647, and rs7229005 were associated with changes in GFR (-8.5ml/min per copy of the G allele; p=0.04; 18.8ml/min per copy of the C allele; p=0.03; and -13.4ml/min per copy of the C allele; p=0.001, respectively). These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease.
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