ArticleJournal of neuroscience methods2011
Computerized detection and analysis of cancer chemotherapy-induced emesis in a small animal model, musk shrew.
Article in Journal of neuroscience methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Characterizing a new tool to manipulate area postrema GLP1RPhysiology & behavior · 2024Article
- Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis.Laboratory animals · 2017Article
- Role of the abdominal vagus and hindbrain in inhalational anesthesia-induced vomiting.Autonomic neuroscience : basic & clinical · 2017Article
- Brain Activation by HFrontiers in physiology · 2017Article
- Detection of Nausea-Like Response in Rats by Monitoring Facial Expression.Frontiers in pharmacology · 2016Article
- Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews.Cancer chemotherapy and pharmacology · 2015Article
- Measuring the nausea-to-emesis continuum in non-human animals: refocusing on gastrointestinal vagal signaling.Experimental brain research · 2014Review
- Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Why can't rodents vomit? A comparative behavioral, anatomical, and physiological study.PloS one · 2013Article
- Post-anesthesia vomiting: impact of isoflurane and morphine on ferrets and musk shrews.Physiology & behavior · 2012Article
- Behavioral patterns associated with chemotherapy-induced emesis: a potential signature for nausea in musk shrews.Frontiers in neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Vomiting is a common side effect of cancer chemotherapy and many drug treatments and diseases. In animal studies, the measurement of vomiting usually requires direct observation, which is time consuming and often lacks temporal precision. Musk shrews have been used to study the neurobiology of emesis and have a rapid emetic episode (∼1 s for a sequence of retching and expulsion). The aim of the current study was to develop a method to automatically detect and characterize emetic episodes induced by the cancer chemotherapy agent cisplatin. The body contour in each video frame was tracked and normalized to a parameterized shape basis. The tracked shape was projected to a feature space that maximized the shape variations in the consecutive frames during retching. The resulting one dimensional projection was sufficient to detect most emetic episodes in the acute (peak at 2h) and delayed (peak at 54 h) phases after cisplatin treatment. Emetic episodes were relatively invariant in the number of retches (∼6.2), duration (∼1.2s), inter-retch interval (∼198 ms), and amplitude during the 72 h after cisplatin treatment. This approach should open a new vista into emesis research to permit tracking and analysis of emesis in a small animal model and facilitate the development of new antiemetic therapies. These results also yield a better understanding of the brain's central pattern generator for emesis and indicate that the retching response in the musk shrew (at ∼5.4 Hz) is the fastest ever recorded in a free-moving animal.
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Registered trials
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