ReviewJournal of child psychology and psychiatry, and allied disciplines2011
Annual Research Review: Developmental considerations of gene by environment interactions.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Cognitive ability in childhood predicts adolescent structural and functional brain development: A longitudinal study.Developmental cognitive neuroscience · 2026Article
- The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project.Frontiers in psychiatry · 2026Review
- Exploring predictive factors of physiological, biochemical indicators, and lifestyle for macrovascular complications in type 2 diabetes: a synthesis of machine learning models.Frontiers in endocrinology · 2026Article
- Association of perinatal factors with neurodevelopmental referrals in a population-based cohort study in Japan.Scientific reports · 2024Article
- Stress in the onset and aggravation of learning disabilities.Developmental review : DR · 2021Article
- Modelling and Refining Neuronal Circuits with Guidance Cues: Involvement of Semaphorins.International journal of molecular sciences · 2021Review
- Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.Journal of youth and adolescence · 2020Article
- Heritability of aggression following social evaluation in middle childhood: An fMRI study.Human brain mapping · 2018Article
- PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Teacher-Evaluated Self-Regulation Is Related to School Achievement and Influenced by Parental Education in Schoolchildren Aged 8-12: A Case-Control Study.Frontiers in psychology · 2018Article
- 'Developmental Delay' Reconsidered: The Critical Role of Age-Dependent, Co-variant Development.Frontiers in psychology · 2018Article
- Boy-Girl Differences in Pictorial Verbal Learning in Students Aged 8-12 Years and the Influence of Parental Education.Frontiers in psychology · 2018Article
- Teacher Evaluations of Executive Functioning in Schoolchildren Aged 9-12 and the Influence of Age, Sex, Level of Parental Education.Frontiers in psychology · 2017Article
- The BDNF Val66Met Polymorphism Interacts with Maternal Parenting Influencing Adolescent Depressive Symptoms: Evidence of Differential Susceptibility Model.Journal of youth and adolescence · 2016Article
- The Roots of Alzheimer's Disease: Are High-Expanding Cortical Areas Preferentially Targeted?†.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- The Dopamine D2 Receptor Polymorphism (DRD2 TaqIA) Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms: Evidence of Differential Susceptibility and Age Differences.Journal of youth and adolescence · 2015Article
- Antecedents and sex/gender differences in youth suicidal behavior.World journal of psychiatry · 2014Review
- Neural effects of the social environment.Schizophrenia bulletin · 2014Review
- Nutrition and neurodevelopment in children: focus on NUTRIMENTHE project.European journal of nutrition · 2013Review
- The 5-HTTLPR polymorphism in the serotonin transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time.Emotion (Washington, D.C.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Biological development is driven by a complex dance between nurture and nature, determined not only by the specific features of the interacting genetic and environmental influences but also by the timing of their rendezvous. The initiation of large-scale longitudinal studies, ever-expanding knowledge of genetics, and increasing availability of neuroimaging data to provide endophenotypic bridges between molecules and behavior are beginning to provide some insight into interactions of developmental stage, genes, and the environment, although daunting challenges remain. Prominent amongst these challenges are difficulties in identifying and quantifying relevant environmental factors, discerning the relative contributions to multiply determined outcomes, and the likelihood that brain development is a non-linear dynamic process in which small initial differences may yield large later effects. Age-sensitive mechanisms include developmental changes in gene expression, epigenetic modifications, synaptic arborization/pruning, and maturational improvements in our capacity to seek out environments of our choosing. Greater understanding of how genetic and environmental factors interact differently across ages is an important step toward elucidating the mechanisms by which phenotypes are created - and how they may differ in health and disease. This knowledge may also provide clues to guide the type and timing of interventions to maximize outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.