ReviewRegenerative medicine2011
Role of mechanical factors in fate decisions of stem cells.
Review in Regenerative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed.
- Modulating cell surface chemistry through mild reduction reinforces extracellular-to-intracellular transmission forces and mechano-signaling.Materials today. Bio · 2026Article
- Next-Generation Joint-on-a-Chip: Toward Precision Mechanical Control in Multi-Tissue Systems.Nano-micro letters · 2026Review
- The effects of blast-induced traumatic brain injury on brain cellular mechanics and differentiation.PloS one · 2026Article
- Article
- Towards a Comprehensive Framework for Made-to-Measure Alginate Scaffolds for Tissue Engineering Using Numerical Simulation.Gels (Basel, Switzerland) · 2025Article
- Directed Differentiation of Adipose-Derived Stem Cells Using Imprinted Cell-Like Topographies as a Growth Factor-Free Approach.Stem cell reviews and reports · 2024Review
- Advances in Shear Stress Stimulation of Stem Cells: A Review of the Last Three Decades.Biomedicines · 2024Review
- OctoShaker: A versatile robotic biomechanical agitator for cellular and organoid research.The Review of scientific instruments · 2023Article
- Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis.Bioactive materials · 2023Review
- Altered Mesenchymal Stem Cells Mechanotransduction from Oxidized Collagen: Morphological and Biophysical Observations.International journal of molecular sciences · 2023Article
- Effect of whole body vibration therapy in the rat model of steroid-induced osteonecrosis of the femoral head.Frontiers in cell and developmental biology · 2023Article
- 3D printing a biocompatible elastomer for modeling muscle regeneration after volumetric muscle loss.Biomaterials advances · 2022Article
- Additive Manufacturing of Viscoelastic Polyacrylamide Substrates for Mechanosensing Studies.ACS omega · 2022Article
- Impact of Treadmill Interval Running on the Appearance of Zinc Finger Protein FHL2 in Bone Marrow Cells in a Rat Model: A Pilot Study.Life (Basel, Switzerland) · 2022Article
- Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche.Frontiers in cell and developmental biology · 2022Review
- The potential therapeutic role of extracellular vesicles in osteoarthritis.Frontiers in bioengineering and biotechnology · 2022Review
- Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications.Bioactive materials · 2021Article
- Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review).Molecular medicine reports · 2021Review
- Lessons from the Embryo: an Unrejected Transplant and a Benign Tumor.Stem cell reviews and reports · 2021Review
- Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Stem cells derived from adult tissues or from the inner cell mass of blastocyst-stage embryos can self-renew in culture and have the remarkable potential to undergo lineage-specific differentiation. Extensive studies have been devoted to achieving a better understanding of the soluble factors and the mechanism(s) by which they regulate the fate decisions of these cells, but it is only recently that a critical role has been revealed for physical and mechanical factors in controlling self-renewal and lineage specification. This review summarizes selected aspects of current work on stem cell mechanics with an emphasis on the influence of matrix stiffness, surface topography, cell shape and mechanical forces on the fate determination of mesenchymal stem cells and embryonic stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.