ReviewRegenerative medicine2011
Stem cell technology for the study and treatment of motor neuron diseases.
Review in Regenerative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase l, Open-label, First in Human, Feasibility and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis
Phase I Clinical Study of Intracerebral Transplantation of Neural Stem Cells for the Treatment of Ischemic Stroke
Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Modeling Alzheimer's Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling.Brain sciences · 2025Review
- Prussian blue nanocubes as a multimodal contrast agent for image-guided stem cell therapy of the spinal cord.Photoacoustics · 2020Article
- Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2019Review
- Overexpression of SMN2 Gene in Motoneuron-Like Cells Differentiated from Adipose-Derived Mesenchymal Stem Cells by Ponasterone A.Journal of molecular neuroscience : MN · 2019Article
- Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017).Cell transplantation · 2018Article
- Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells.Stem cells international · 2018Article
- Inhibitor of PI3K/Akt Signaling Pathway Small Molecule Promotes Motor Neuron Differentiation of Human Endometrial Stem Cells Cultured on Electrospun Biocomposite Polycaprolactone/Collagen Scaffolds.Molecular neurobiology · 2017Article
- Neuroprotective Potential of Cell-Based Therapies in ALS: From Bench to Bedside.Frontiers in neuroscience · 2017Review
- Autologous Bone Marrow Derived Stem Cells for the Treatment of Multiple Sclerosis.International journal of stem cells · 2016Article
- Reverse engineering human neurodegenerative disease using pluripotent stem cell technology.Brain research · 2016Review
- Intraspinal stem cell transplantation for amyotrophic lateral sclerosis.Annals of neurology · 2016Review
- Mesenchymal Stem Cells Derived from Dental Pulp: A Review.Stem cells international · 2016Review
- Mechanisms of human amniotic epithelial cell transplantation in treating stage III pressure ulcer in a rat model.Experimental and therapeutic medicine · 2015Article
- Induction of human umbilical Wharton's jelly-derived mesenchymal stem cells toward motor neuron-like cells.In vitro cellular & developmental biology. Animal · 2015Article
- Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- Stem cell therapy for amyotrophic lateral sclerosis.Cell regeneration (London, England) · 2015Article
- Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development.Experimental neurobiology · 2014Review
- Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation.Cellular and molecular life sciences : CMLS · 2014Review
- Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives.Stem cell research & therapy · 2014Review
- Concise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future.Stem cells (Dayton, Ohio) · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Amyotrophic lateral sclerosis and spinal muscular atrophy are devastating neurodegenerative diseases that lead to the specific loss of motor neurons. Recently, stem cell technologies have been developed for the investigation and treatment of both diseases. Here we discuss the different stem cells currently being studied for mechanistic discovery and therapeutic development, including embryonic, adult and induced pluripotent stem cells. We also present supporting evidence for the utilization of stem cell technology in the treatment of amyotrophic lateral sclerosis and spinal muscular atrophy, and describe key issues that must be considered for the transition of stem cell therapies for motor neuron diseases from bench to bedside. Finally, we discuss the first-in-human Phase I trial currently underway examining the safety and feasibility of intraspinal stem cell injections in amyotrophic lateral sclerosis patients as a foundation for translating stem cell therapies for various neurological diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.