ArticleJournal of medicinal chemistry2011
Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.
Article in Journal of medicinal chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Translational molecular imaging and drug development in multiple sclerosis.Theranostics · 2026Review
- Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024Review
- Shining a Light on Venom-Peptide Receptors: Venom Peptides as Targeted Agents for In Vivo Molecular Imaging.Toxins · 2024Review
- Synthesis, DFT studies on a series of tunable quinoline derivatives.RSC advances · 2024Article
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- 3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade.Molecules (Basel, Switzerland) · 2021Review
- Positron emission tomography in multiple sclerosis - straight to the target.Nature reviews. Neurology · 2021Review
- Coumarins as Tool Compounds to Aid the Discovery of Selective Function Modulators of Steroid Hormone Binding Proteins.Molecules (Basel, Switzerland) · 2021Review
- Nerve Segmentation with Deep Learning from Label-Free Endoscopic Images Obtained Using Coherent Anti-Stokes Raman Scattering.Biomolecules · 2020Article
- Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture.Journal of fluorescence · 2019Article
- Article
- Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability.Brain pathology (Zurich, Switzerland) · 2018Review
- Development of a PET radioligand for potassium channels to image CNS demyelination.Scientific reports · 2018Article
- Nerve-targeted probes for fluorescence-guided intraoperative imaging.Theranostics · 2018Article
- Imaging Central Nervous System Demyelination and Remyelination by Positron-Emission Tomography.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- Quantification of [(11)C]PIB PET for imaging myelin in the human brain: a test-retest reproducibility study in high-resolution research tomography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Synthesis and characterization of a novel gadolinium-based contrast agent for magnetic resonance imaging of myelination.Journal of medicinal chemistry · 2013Article
- A NIR Dye for Development of Peripheral Nerve Targeted Probes.MedChemComm · 2012Article
- Myelin imaging compound (MIC) enhanced magnetic resonance imaging of myelination.Journal of medicinal chemistry · 2012Article
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Authors and funding
5 authors.
Funding
Abstract
Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many neurodegenerative disorders, such as multiple sclerosis (MS). A long-standing goal has been to directly detect and quantify myelin content in order to facilitate diagnosis and therapeutic treatments of myelin-related diseases. In the course of our studies, we have developed a series of small-molecule probes (SMP) as myelin-imaging agents. Among them are coumarin derivatives, which exhibit promising brain permeability and myelin-binding properties. Herein we report a full account of the design and synthesis of coumarin-based SMPs as myelin-imaging agents. Systematic evaluation of these SMPs in both the CNS and peripheral nervous system (PNS) allowed us to identify some lead agents for potential use as fluorescent dyes for intraoperative nerve mapping in surgical operations or as radiotracers for positron emission tomography (PET) imaging of myelination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.