ArticleHuman brain mapping2012
Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.
Article in Human brain mapping, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Interpretable machine learning to evaluate relationships between DAO/DAOA (pLG72) protein data and features in clinical assessments, functional outcome, and cognitive function in schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2025Article
- Sex differences in multilayer functional network topology over the course of aging in 37543 UK Biobank participants.Network neuroscience (Cambridge, Mass.) · 2023Article
- Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.Brain imaging and behavior · 2021Article
- D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?Frontiers in psychiatry · 2019Review
- A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.Human brain mapping · 2015Article
- Expression of the G72/G30 gene in transgenic mice induces behavioral changes.Molecular psychiatry · 2014Article
- Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function.Human brain mapping · 2013Article
- Connectomic intermediate phenotypes for psychiatric disorders.Frontiers in psychiatry · 2012Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundThe D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder.
aimsTo examine the influence of G72 variation on brain function in the healthy population.
methodFifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes.
resultsG72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05).
conclusionsOur results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis.
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