ArticleHuman brain mapping2011
Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocation.
Article in Human brain mapping, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Grey matter volume differences in pediatric obsessive-compulsive disorder: a meta-analysis of voxel-based morphometry studies.BMC psychiatry · 2025Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Biological psychiatry · 2014Pooled it
- Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2012Pooled it
- Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit/hyperactivity disorder.Biological psychiatry · 2011Trial
- Methylphenidate normalizes fronto-striatal underactivation during interference inhibition in medication-naïve boys with attention-deficit hyperactivity disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Brain functional abnormalities: a bridge between insulin signaling pathway gene polymorphisms and clinical cognition in early-onset obsessive-compulsive disorder.European child & adolescent psychiatry · 2026Article
- Assessing the effects of methylphenidate in proliferation and Wnt activity of neuronal stem cells from attention deficit/hyperactivity disorder patients.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Article
- Cognitive-attentional mechanisms of cooperation-with implications for attention-deficit hyperactivity disorder and cognitive neuroscience.Cognitive, affective & behavioral neuroscience · 2023Article
- Defining brain-based OCD patient profiles using task-based fMRI and unsupervised machine learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Near-infrared spectroscopy in child and adolescent neurodevelopmental disorders.PCN reports : psychiatry and clinical neurosciences · 2022Review
- Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder.Translational psychiatry · 2021Review
- Complexity of information processing in obsessive-compulsive disorder based on fractal analysis of EEG signal.EXCLI journal · 2021Article
- Case Report: Treatment of a Comorbid Attention Deficit Hyperactivity Disorder and Obsessive-Compulsive Disorder With Psychostimulants.Frontiers in psychiatry · 2021Article
- Using virtual reality to define the mechanisms linking symptoms with cognitive deficits in attention deficit hyperactivity disorder.Scientific reports · 2020Article
- Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families.NeuroImage. Clinical · 2020Article
- Pediatric OCD in the era of RDoC.Journal of obsessive-compulsive and related disorders · 2019Article
- Evidence for an altered architecture and a hierarchical modulation of inhibitory control processes in ADHD.Developmental cognitive neuroscience · 2019Article
- Co-Morbid Obsessive-Compulsive Disorder and Attention Deficit Hyperactivity Disorder: Neurobiological Commonalities and Treatment Implications.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAbnormalities in inhibitory control and underlying fronto-striatal networks is common to both attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive-disorder (OCD). The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition and selective attention.
methodEvent-related functional magnetic resonance imaging (fMRI) was used to compare brain activation of boys with ADHD (18), with OCD (10), and healthy boys during (20) during a Simon task that measures interference inhibition and controls for and therefore comeasures attention allocation.
resultsDuring interference inhibition, both patient groups shared mesial frontal dysfunction compared to controls. Disorder-specific dysfunctions were observed in OCD patients in dorsolateral prefrontal cortex during the oddball condition and in ADHD patients in inferior parietal lobe during interference inhibition and in caudate and posterior cingulate during the simpler oddball condition. The decreased activation in caudate and cingulate in ADHD was furthermore negatively correlated with ADHD symptoms and positively with OCD behavioral traits.
conclusionsThe study shows that ADHD and OCD patients have shared but also disorder-specific brain dysfunctions during interference inhibition and attention allocation. Both disorders shared dysfunction in mesial frontal cortex. Disorder-specific dysfunctions, however, were observed in dorsolateral prefrontal cortex in OCD patients and in caudate, cingulate, and parietal brain regions in ADHD patients. The disorder-specific dissociation of striato-cingulate activation that was increased in OCD compared to ADHD patients, was furthermore inversely related to the symptomatology of the two disorders, and may potentially reflect differential dopamine modulation of striatal brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.