Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Association of oral mucositis with quality of life and symptom clusters in patients with solid tumors receiving chemotherapy.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Efficacy of different pharmaceutical forms ofFrontiers in pharmacology · 2025Pooled it
- Development of Freeze-Dried Hyaluronic Acid Sheets for Healing Oral Mucositis: Influence of Hyaluronic Acid Molecular Weight and Nicotinamide Mononucleotide Loading on Healing Efficacy.Journal of functional biomaterials · 2026Article
- Nuclear Receptors and Stress Response Pathways Associated with the Development of Oral Mucositis Induced by Antineoplastic Agents.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The Impact of Dermatologic Adverse Events on the Quality of Life of Oncology Patients: A Review of the Literature.American journal of clinical dermatology · 2024Review
- Study of prevalence and risk factors of chemotherapy-induced mucositis in gastrointestinal cancer using machine learning models.Frontiers in oncology · 2023Article
- Moderate temperature reduction is sufficient for prevention of 5-fluorouracil-induced oral mucositis: an experimental in vivo study in rats.Cancer chemotherapy and pharmacology · 2023Article
- Factors influencing patient disclosure of cancer diagnosis to the family dentist: online survey in Japan.Scientific reports · 2022Article
- Chemotherapy-associated oral complications in a south Indian population: a cross-sectional study.Journal of medicine and life · 2022Article
- The influence of antineoplastic agents on the peri-implant bone around osseointegrated titanium implants: an in vivo histomorphometric and immunohistochemical study.Clinical oral investigations · 2022Article
- Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature.European journal of investigation in health, psychology and education · 2020Review
- Impact of oral mucositis on quality of life in patients undergoing oncological treatment: a systematic review.Translational cancer research · 2020Review
- Dermatologic conditions in women receiving systemic cancer therapy.International journal of women's dermatology · 2019Review
- Burden of oral mucositis in stem cell transplant patients-the patients' perspective.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- The effect of preventive oral care on treatment outcomes of a cohort of oral cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Tachykinin peptide, substance P, and its receptor NK-1R play an important role in alimentary tract mucosal inflammation during cytotoxic therapy.Digestive diseases and sciences · 2014Review
- Supportive cryotherapy: a review from head to toe.Journal of pain and symptom management · 2014Review
- Severe oral mucositis relating to pain and worse oral condition among patients with solid tumors undergoing treatment with FOLFIRI and 5-FU: a retrospective study.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aims to determine whether or not oral mucositis (OM) during active chemotherapy in patients with solid tumors is representative of the patient's quality of life (QOL) and the suffering from adverse effects.
methodsFrom October 2007 to September 2008, we prospectively enrolled 344 consecutive patients with solid tumors who initiated a new chemotherapy regimen. OM, other adverse effects, and the QOL were surveyed by face-to-face interviews and patient diaries.
resultsOM developed during 175 of 633 cycles (27.7%). Forty-five percent of the patients experienced OM during two cycles of chemotherapy. The QOL in patients with OM was significantly lower than patients without OM, as evaluated by the Functional Assessment of Cancer Therapy-General (70.26 ± 15.36 and 75.09 ± 13.12, respectively; p < 0.001). Specifically, the physical and emotional well-being was lower in patients with OM compared with patients without OM. Moreover, other adverse effects were more frequent in chemotherapy cycles with OM compared with chemotherapy cycles without OM (amount of food intake, activity, nausea, vomiting, fever, myalgias, and sensory neuropathy; p < 0.001, p = 0.008, p < 0.001, p = 0.001, p = 0.002, p < 0.001, and p < 0.001, respectively).
conclusionsOM represents poor QOL and is a basic symptom of symptom clusters in patients with solid tumors receiving active chemotherapy.
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