ArticleImmunogenetics2011
Molecular evolution of immunoglobulin superfamily genes in primates.
Article in Immunogenetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.Genome biology and evolution · 2026Article
- Analysis of lncRNA-mRNA expression pattern in male textile workers with noise-induced hearing loss.Annals of translational medicine · 2019Article
- ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Molecular Evolution and Functional Divergence of the IgLON Family.Evolutionary bioinformatics online · 2018Article
- Neonatal screening and a new cause of congenital central hypothyroidism.Annals of pediatric endocrinology & metabolism · 2014Review
- Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates.Immunogenetics · 2012Article
- Role of TIM-4 in innate or adaptive immune response.North American journal of medical sciences · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes of the immunoglobulin superfamily (IgSF) have a wide variety of cellular activities. In this study, we investigated molecular evolution of IgSF genes in primates by comparing orthologous sequences of 249 IgSF genes among human, chimpanzee, orangutan, rhesus macaque, and common marmoset. To evaluate the non-synonymous/synonymous substitution ratio (ω), we applied Bn-Bs program and PAML program. IgSF genes were classified into 11 functional categories based on the Gene Ontology (GO) database. Among them, IgSF genes in three functional categories, immune system process (GO:0002376), defense response (GO:0006952), and multi-organism process (GO:0051704), which are tightly linked to the regulation of immune system had much higher values of ω than genes in the other GO categories. In addition, we estimated the average values of ω for each primate lineage. Although each primate lineage had comparable average values of ω, the human lineage showed the lowest ω value for the immune-related genes. Furthermore, 11 IgSF genes, SIGLEC5, SLAMF6, CD33, CD3E, CEACAM8, CD3G, FCER1A, CD48, CD4, TIM4, and FCGR2A, were implied to have been under positive selective pressure during the course of primate evolution. Further sequence analyses of CD3E and CD3G from 23 primate species suggested that the Ig domains of CD3E and CD3G underwent the positive Darwinian selection.
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