Evidence map›Paper›PMID 21390502›Full record

ArticleMolecular biology reports2011

DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma.

Ayse Basak Engin, Bensu Karahalil, Atilla Engin, Ali Esat Karakaya

Abstract read
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In one paragraph

Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 11 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 11 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  3. The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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  12. Article
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  15. Analysis of DNA Repair Genes Polymorphisms in Breast Cancer.Pathology oncology research : POR · 2017
    Article
  16. Review
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  18. Article
  19. Correlation Between Nuclear Factor E2-Related Factor 2 Expression and Gastric Cancer Progression.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ayse Basak EnginDepartment of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Hipodrom, Ankara, Turkey. abengin@gmail.com
Bensu Karahalil
Atilla Engin
Ali Esat Karakaya
Gazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the developmental stages of gastric carcinoma are still not clear, the constantly generated reactive oxygen and nitrogen species (ROS/RNS) may contribute to the process of carcinogenesis by interacting with DNA. 8-oxoguanine DNA glycosylase-1 (OGG1) is an enzyme involved in base excision repair of 8-oxoguanine that is one of the premutagenic lesions generated by ROS in DNA. The bulky adducts, are recognized and repaired by nucleotid excision repair (NER) enzymes, including xeroderma pigmentosum C and D (XPC, XPD). Eligible 106 gastric cancer patients and 116 cancer-free individuals constituted the study and control groups, respectively. Association between OGG1 Ser326Cys, XPC Lys939Gln, XPD Lys751Gln polymorphisms and the susceptibility tho cancer and the oxidative stress status were evaluated. DNA was extracted from peripheral blood cells and genotypes were determined by using PCR-RFLP. Serum nitric oxide, albumin concentrations, total antioxidant status and Helicobacter pylori IgG were determined. Serum albumin and nitric oxide of cancer patients were lower than that of the controls (P < 0.05). None of the evaluated polymorphisms or Helicobacter pylori IgG seropositivity associated with increased risk of gastric cancer, despite of the increased oxidative stress in cancer patients.

Indexed as

Genetic Predisposition to DiseaseCase-Control StudiesDNA-Binding ProteinsDNA GlycosylasesDNA Repair EnzymesGene FrequencyGenetics, PopulationHelicobacter pyloriHumansImmunoglobulin GMiddle AgedOdds RatioOxidative StressPolymorphism, Single NucleotideRisk FactorsStomach NeoplasmsDNA-Binding ProteinsDNA GlycosylasesDNA Repair EnzymesERCC2 protein, humanImmunoglobulin Goxoguanine glycosylase 1, humanXeroderma Pigmentosum Group D ProteinXPC protein, human

Identifiers

PMID21390502
OpenAlexW2094228664

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.