ArticleThe Journal of cell biology1990
An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 158 citations in OpenAlex.
- Monoallelic de novoScience advances · 2024Article
- Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Mechanisms for the maintenance and regulation of axonal energy supply.Journal of neuroscience research · 2019Review
- Reversible white matter lesions associated with mutant EHMT1 and Kleefstra syndrome.Neurology. Genetics · 2016Article
- Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.The Journal of biological chemistry · 2014Article
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- The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM function.Cellular & molecular biology letters · 2009Review
- Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G.The Journal of cell biology · 2008Article
- Tumor suppressor schwannomin/merlin is critical for the organization of Schwann cell contacts in peripheral nerves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Ankyrin-linked hereditary spherocytosis in an African-American kindred.American journal of hematology · 2008Article
- Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.The Journal of cell biology · 2004Article
- Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier.The Journal of cell biology · 2003Article
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- Ankyrin gene mutations in japanese patients with hereditary spherocytosis.International journal of hematology · 2001Article
- betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.The Journal of cell biology · 2000Article
- Axo-glial interactions regulate the localization of axonal paranodal proteins.The Journal of cell biology · 1999Article
- Voltage-dependent sodium channel function is regulated through membrane mechanics.Biophysical journal · 1999Article
- Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Two variants of ankyrin have been distinguished in rat brain tissue using antibodies: a broadly distributed isoform (ankyrinB) that represents the major form of ankyrin in brain and another isoform with a restricted distribution (ankyrinR) that shares epitopes with erythrocyte ankyrin. The ankyrinR isoform was localized by immunofluorescence in cryosections of rat spinal cord gray matter and myelinated central and peripheral nerves to: (a) perikarya and initial axonal segments of neuron cells, (b) nodes of Ranvier of myelinated nerve with no detectable labeling in other areas of the myelinated axons, and (c) the axolemma of unmyelinated axons. Immunogold EM on ultrathin cryosections of myelinated nerve showed that ankyrinR was localized on the cytoplasmic face of the axolemma and was restricted to the nodal and, in some cases, paranodal area. The major isoform of ankyrin in brain (ankyrinB) displayed a broad distribution on glial and neuronal cells of the gray matter and a mainly glial distribution in central myelinated axons with no significant labeling on the axolemma. These results show that (a) ankyrin isoforms display a differential distribution on glial and neuronal cells of the nervous tissue; (b) an isoform of ankyrin codistributes with the voltage-dependent sodium channel in both myelinated and unmyelinated nerve fibers. Ankyrin interacts in vitro with the voltage-dependent sodium channel (Srinivasan, Y., L. Elmer, J. Davis, V. Bennett, and K. Angelides. 1988. Nature (Lond.). 333:177-180). A specific interaction of an isoform of ankyrin with the sodium channel thus may play an important role in the morphogenesis and/or maintenance of the node of Ranvier.
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