Evidence map›Paper›PMID 21390320›Full record

ArticlePloS one2011

Fluid status in peritoneal dialysis patients: the European Body Composition Monitoring (EuroBCM) study cohort.

Wim Van Biesen, John D Williams, Adrian C Covic, Stanley Fan, Kathleen Claes, Monika Lichodziejewska-Niemierko, Christian Verger, Jurg Steiger, Volker Schoder, Peter Wabel and 3 more

Registry-linked trialAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01887262 (Control Of Fluid Balance Guided by Body Composition Monitoring in Patients on PeritoneAl dialySiS), which is not on this map. Cited by 104 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01887262 nacompletednot on this mapstarted 2013, after this paper: background citation

Control Of Fluid Balance Guided by Body Composition Monitoring in Patients on PeritoneAl dialySiS (COMPASS) Trial

TypeinterventionalSponsorSeoul National University HospitalRan2013 to 2016Enrolled108ConditionsPeritoneal Dialysis, Continuous AmbulatoryArmsBCM-guided fluid management, Fluid management based on the clinical information alone
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Trial
  7. Trial
  8. Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
    Trial
  9. Article
  10. Article
  11. Article
  12. Volume Assessment in Patients Undergoing Long-Term Dialysis.Journal of the American Society of Nephrology : JASN · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wim Van BiesenUniversity Hospital Ghent, Ghent, Belgium.
John D Williams
Adrian C Covic
Stanley Fan
Kathleen Claes
Monika Lichodziejewska-Niemierko
Christian Verger
Jurg Steiger
Volker Schoder
Peter Wabel
Adelheid Gauly
Rainer Himmele
EuroBCM Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEuvolemia is an important adequacy parameter in peritoneal dialysis (PD) patients. However, accurate tools to evaluate volume status in clinical practice and data on volume status in PD patients as compared to healthy population, and the associated factors, have not been available so far.

methodsWe used a bio-impedance spectroscopy device, the Body Composition Monitor (BCM) to assess volume status in a cross-sectional cohort of prevalent PD patients in different European countries. The results were compared to an age and gender matched healthy population.

resultsOnly 40% out of 639 patients from 28 centres in 6 countries were normovolemic. Severe fluid overload was present in 25.2%. There was a wide scatter in the relation between blood pressure and volume status. In a multivariate analysis in the subgroup of patients from countries with unrestricted availability of all PD modalities and fluid types, older age, male gender, lower serum albumin, lower BMI, diabetes, higher systolic blood pressure, and use of at least one exchange per day with the highest hypertonic glucose were associated with higher relative tissue hydration. Neither urinary output nor ultrafiltration, PD fluid type or PD modality were retained in the model (total R² of the model = 0.57).

conclusionsThe EuroBCM study demonstrates some interesting issues regarding volume status in PD. As in HD patients, hypervolemia is a frequent condition in PD patients and blood pressure can be a misleading clinical tool to evaluate volume status. To monitor fluid balance, not only fluid output but also dietary input should be considered. Close monitoring of volume status, a correct dialysis prescription adapted to the needs of the patient and dietary measures seem to be warranted to avoid hypervolemia.

Indexed as

Peritoneal DialysisAdultAgedBody CompositionBody FluidsCase-Control StudiesCohort StudiesCross-Sectional StudiesDielectric SpectroscopyEuropeFemaleHealth StatusHumansKidney Failure, ChronicMaleMiddle Aged

Identifiers

PMID21390320
PMCPMC3044747

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.