Evidence map›Paper›PMID 21390303›Full record

ArticlePloS one2011

A folding pathway-dependent score to recognize membrane proteins.

Hamid Hadi-Alijanvand, Maryam Rouhani, Elizabeth A Proctor, Nikolay V Dokholyan, Ali A Moosavi-Movahedi

Abstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hamid Hadi-AlijanvandInstitute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Maryam Rouhani
Elizabeth A Proctor
Nikolay V Dokholyan
Ali A Moosavi-Movahedi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While various approaches exist to study protein localization, it is still a challenge to predict where proteins localize. Here, we consider a mechanistic viewpoint for membrane localization. Taking into account the steps for the folding pathway of α-helical membrane proteins and relating biophysical parameters to each of these steps, we create a score capable of predicting the propensity for membrane localization and call it FP(3)mem. This score is driven from the principal component analysis (PCA) of the biophysical parameters related to membrane localization. FP(3)mem allows us to rationalize the colocalization of a number of channel proteins with the Cav1.2 channel by their fewer propensities for membrane localization.

Indexed as

Protein FoldingAnimalsCalcium ChannelsDatabases, ProteinEukaryotic CellsHumansMembrane ProteinsProkaryotic CellsProtein Structure, SecondaryProtein TransportReceptors, AMPAReceptors, N-Methyl-D-AspartateCalcium ChannelsMembrane ProteinsReceptors, AMPAReceptors, N-Methyl-D-Aspartate

Identifiers

PMID21390303
PMCPMC3046963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.