ArticleWorld journal of gastroenterology2011
Perinatal and early life risk factors for inflammatory bowel disease.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Mode of Delivery Does Not Affect the Risk of Inflammatory Bowel Disease.Digestive diseases and sciences · 2021Pooled it
- Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: a systematic review.The American journal of clinical nutrition · 2019Pooled it
- Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis.PLoS medicine · 2018Pooled it
- Systematic review with meta-analysis: breastfeeding and the risk of Crohn's disease and ulcerative colitis.Alimentary pharmacology & therapeutics · 2017Pooled it
- Trial
- Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mode of birth and risk of inflammatory bowel disease in offspring: an updated systematic review and meta-analysis.Frontiers in reproductive health · 2026Review
- Parental and perinatal risk factors associated with onset of IBD: a systematic literature review and meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Review
- Childhood Socioeconomic Characteristics and Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study.Inflammatory bowel diseases · 2024Article
- Pregnancy period and early-life risk factors for inflammatory bowel disease: a Northern Finland birth cohort 1966 study.BMC public health · 2024Article
- Amyloid, Crohn's disease, and Alzheimer's disease - are they linked?Frontiers in cellular and infection microbiology · 2024Review
- An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease.Nutrients · 2023Review
- Food as Treatment of Inflammatory Bowel Diseases.Infection and immunity · 2022Review
- Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.Frontiers in immunology · 2022Review
- Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions.Neuroscience and biobehavioral reviews · 2021Review
- Early Life Modifiable Exposures and Their Association With Owner Reported Inflammatory Bowel Disease Symptoms in Adult Dogs.Frontiers in veterinary science · 2021Article
- Association between Passive Smoking from the Mother and Pediatric Crohn's Disease: A Japanese Multicenter Study.International journal of environmental research and public health · 2020Article
- Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973-2016.Clinical epidemiology · 2020Article
- Antibiotic use is a negative predictor of the efficacy and toxicity of epidermal growth factor receptor-targeted therapy in advanced non-small cell lung cancer.Oncology letters · 2019Article
- Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.Cellular and molecular gastroenterology and hepatology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.
methodsRecord linked abstracts of birth registrations, maternity, day case and inpatient admissions in a defined population of southern England. Investigation of 20 perinatal factors relating to the maternity or the birth: maternal age, Crohn's disease (CD) or ulcerative colitis (UC) in the mother, maternal social class, marital status, smoking in pregnancy, ABO blood group and rhesus status, pre-eclampsia, parity, the infant's presentation at birth, caesarean delivery, forceps delivery, sex, number of babies delivered, gestational age, birthweight, head circumference, breastfeeding and Apgar scores at one and five minutes.
resultsMaternity records were present for 180 children who subsequently developed IBD. Univariate analysis showed increased risks of CD among children of mothers with CD (P = 0.011, based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy. Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio = 2.04, 95% CI = 1.06-3.92) and for older mothers aged 35+ years (4.81, 2.32-9.98). Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated. It also showed that, for UC, there were no significant associations with the perinatal factors studied.
conclusionThis study shows an association between CD in mother and child; and elevated risks of CD in children of older mothers and of mothers who smoked.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.