ArticleJournal of neurophysiology2011
Vasoactive intestinal polypeptide requires parallel changes in adenylate cyclase and phospholipase C to entrain circadian rhythms to a predictable phase.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 76 citations in OpenAlex.
- An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuronal feedback loop of the suprachiasmatic nucleus generates robust circadian rhythms.Nature communications · 2026Article
- Hypoosmotic stress shifts transcription of circadian genes.Biophysical journal · 2025Article
- Role of circadian clock in female embryo implantation.Frontiers in cell and developmental biology · 2025Review
- Dynamic modulation of genomic enhancer elements in the suprachiasmatic nucleus, the site of the mammalian circadian clock.Genome research · 2023Article
- Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus.Science advances · 2023Article
- Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.International journal of molecular sciences · 2022Article
- Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge.Endocrinology · 2022Review
- Female fertility does not requireFrontiers in endocrinology · 2022Article
- Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.Scientific reports · 2021Article
- Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.Circulation research · 2021Article
- Collective Oscillations in Coupled-Cell Systems.Bulletin of mathematical biology · 2021Article
- Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock.Frontiers in neuroscience · 2021Review
- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- Article
- Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus.Journal of biological rhythms · 2020Article
- Circuit development in the master clock network of mammals.The European journal of neuroscience · 2020Review
- A saturated reaction in repressor synthesis creates a daytime dead zone in circadian clocks.PLoS computational biology · 2019Article
- Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.Nature communications · 2019Article
- SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Circadian oscillations in the suprachiasmatic nucleus (SCN) depend on transcriptional repression by Period (PER)1 and PER2 proteins within single cells and on vasoactive intestinal polypeptide (VIP) signaling between cells. Because VIP is released by SCN neurons in a circadian pattern, and, after photic stimulation, it has been suggested to play a role in the synchronization to environmental light cycles. It is not known, however, if or how VIP entrains circadian gene expression or behavior. Here, we tested candidate signaling pathways required for VIP-mediated entrainment of SCN rhythms. We found that single applications of VIP reset PER2 rhythms in a time- and dose-dependent manner that differed from light. Unlike VIP-mediated signaling in other cell types, simultaneous antagonism of adenylate cyclase and phospholipase C activities was required to block the VIP-induced phase shifts of SCN rhythms. Consistent with this, VIP rapidly increased intracellular cAMP in most SCN neurons. Critically, daily VIP treatment entrained PER2 rhythms to a predicted phase angle within several days, depending on the concentration of VIP and the interval between VIP applications. We conclude that VIP entrains circadian timing among SCN neurons through rapid and parallel changes in adenylate cyclase and phospholipase C activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.