Trial reportJournal of neurophysiology2011
The cortical response to the oral perception of fat emulsions and the effect of taster status.
Trial report in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03670693 (Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Basal ganglia lateralization in different types of reward.Brain imaging and behavior · 2020Pooled it
- Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat.The Journal of nutrition · 2016Trial
- Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.Physiology & behavior · 2025Review
- Perceptual differences in olfactory fat discrimination are not detected in neural activation.Chemical senses · 2025Article
- The gut-brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies.Pharmacology research & perspectives · 2024Review
- Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers.Human brain mapping · 2024Article
- A Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- What is the link between personality and food behavior?Current research in food science · 2022Review
- The Role of Intrinsic and Extrinsic Sensory Factors in Sweetness Perception of Food and Beverages: A Review.Foods (Basel, Switzerland) · 2019Review
- Unbalanced Occlusion Modifies the Pattern of Brain Activity During Execution of a Finger to Thumb Motor Task.Frontiers in neuroscience · 2019Article
- Genetic Taster Status as a Mediator of Neural Activity and Swallowing Mechanics in Healthy Adults.Frontiers in neuroscience · 2019Article
- Fatty Acid Lingual Application Activates Gustatory and Reward Brain Circuits in the Mouse.Nutrients · 2018Article
- Fat perception in the human frontal operculum, insular and somatosensory cortex.Scientific reports · 2018Article
- Sour taste increases swallowing and prolongs hemodynamic responses in the cortical swallowing network.Journal of neurophysiology · 2016Article
- Lipids and obesity: Also a matter of taste?Reviews in endocrine & metabolic disorders · 2016Review
- Thermal taster status: Evidence of cross-modal integration.Human brain mapping · 2016Article
- Understanding Neuronal Architecture in Obesity through Analysis of White Matter Connection Strength.Frontiers in human neuroscience · 2016Article
- Recent advances in fatty acid perception and genetics.Advances in nutrition (Bethesda, Md.) · 2015Review
- Altered salience network connectivity predicts macronutrient intake after sleep deprivation.Scientific reports · 2015Article
- The representation of oral fat texture in the human somatosensory cortex.Human brain mapping · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The rewarding attributes of foods containing fat are associated with the increase in fat consumption, but little is known of how the complex physical and chemical properties of orally ingested fats are represented and decoded in the brain nor how this impacts feeding behavior within the population. Here, functional MRI (fMRI) is used to assess the brain response to isoviscous, isosweet fat emulsions of increasing fat concentration and to investigate the correlation of behavioral and neuroimaging responses with taster status (TS). Cortical areas activated in response to fat, and those areas positively correlated with fat concentration, were identified. Significant responses that positively correlated with increasing fat concentration were found in the anterior insula, frontal operculum and secondary somatosensory cortex (SII), anterior cingulate cortex, and amygdala. Assessing the effect of TS revealed a strong correlation with self-reported preference of the samples and with cortical response in somatosensory areas [primary somatosensory cortex (SI), SII, and midinsula] and the primary taste area (anterior insula) and a trend in reward areas (amygdala and orbitofrontal cortex). This finding of a strong correlation with TS in somatosensory areas supports the theory of increased mechanosensory trigeminal innervation in high 6-n-propyl-2-thiouracil (PROP) tasters and has been linked to a higher risk of obesity. The interindividual differences in blood oxygenation level-dependent (BOLD) amplitude with TS indicates that segmenting populations by TS will reduce the heterogeneity of BOLD responses, improving signal detection power.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.