Evidence map›Paper›PMID 21389250›Full record

ArticleMayo Clinic proceedings2011

Medication adherence: WHO cares?

Marie T Brown, Jennifer K Bussell

5 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mayo Clinic proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 854 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
854citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02957253 nacompletednot on this mapstarted 2016, after this paper: background citation

Effects on Liver Cirrhotic Patient's Health Related Quality of Life by a Nurse-led Clinic: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorUppsala UniversityRan2016 to 2022Enrolled167ConditionsLiver CirrhosisArmsrisk factors, self-care, nutrition, lifestyle, psychosocial needs
NCT03709277 nacompletednot on this mapstarted 2019, after this paper: background citation

Patient-tailored Interventions to Improve Specialty Medication Adherence: Results From a Prospective Randomized Controlled Trial

TypeinterventionalSponsorVanderbilt University Medical CenterRan2019 to 2022Enrolled438ConditionsAdherence, Medication, Nonadherence, MedicationArmsPharmacist-Driven Intervention
NCT03734887 naterminatednot on this mapstarted 2019, after this paper: background citation

Social Engagement Strategies to Improve Medication Adherence Among Older Adults in Los Angeles Count Participating in MyMeds

TypeinterventionalSponsorUniversity of California, Los AngelesRan2019 to 2022Enrolled43ConditionsDiabetes, Atherosclerosis Cardiovascular Disease, Congestive Heart Failure, Poor Medication AdherenceArmsSocial Network Feedback, Private Feedback
NCT03973931 nacompletednot on this mapstarted 2019, after this paper: background citation

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (The Nudge Study)

TypeinterventionalSponsorUniversity of Colorado, DenverRan2019 to 2023Enrolled9,501ConditionsCardiovascular Diseases, Adherence, Medication, Medication Adherence, Diabetes MellitusArmsNudge
NCT06882044 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of a Mobile Application on Treatment Adherence, Self-Management, and Quality of Life in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

TypeinterventionalSponsorTrakya UniversityRan2021 to 2024Enrolled61ConditionsAcute Myocardial Infarction (AMI), Mobile Health Technology (mHealth), Quality of Lifte, Treatment AdherenceArmsmHealth
3 · Its place in the literature

Who cites it

854 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  8. Digital remote maintenance inhaler adherence interventions in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024
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  15. Association of medication adherence with treatment preferences: incentivizing truthful self-reporting.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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794 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Marie T BrownDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. mariebrown@drsbrownforbes.com
Jennifer K Bussell

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of chronic illnesses commonly includes the long-term use of pharmacotherapy. Although these medications are effective in combating disease, their full benefits are often not realized because approximately 50% of patients do not take their medications as prescribed. Factors contributing to poor medication adherence are myriad and include those that are related to patients (eg, suboptimal health literacy and lack of involvement in the treatment decision-making process), those that are related to physicians (eg, prescription of complex drug regimens, communication barriers, ineffective communication of information about adverse effects, and provision of care by multiple physicians), and those that are related to health care systems (eg, office visit time limitations, limited access to care, and lack of health information technology). Because barriers to medication adherence are complex and varied, solutions to improve adherence must be multifactorial. To assess general aspects of medication adherence using cardiovascular disease as an example, a MEDLINE-based literature search (January 1, 1990, through March 31, 2010) was conducted using the following search terms: cardiovascular disease, health literacy, medication adherence, and pharmacotherapy. Manual sorting of the 405 retrieved articles to exclude those that did not address cardiovascular disease, medication adherence, or health literacy in the abstract yielded 127 articles for review. Additional references were obtained from citations within the retrieved articles. This review surveys the findings of the identified articles and presents various strategies and resources for improving medication adherence.

Indexed as

Drug MonitoringAntihypertensive AgentsCardiovascular DiseasesChronic DiseaseComorbidityHealth LiteracyHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInternetMedication AdherencePhysician-Patient RelationsPlatelet Aggregation InhibitorsPower, PsychologicalStrokeWorld Health OrganizationAntihypertensive AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation Inhibitors

Identifiers

PMID21389250
PMCPMC3068890

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.