ArticleJournal of virology2011
Investigation of koi herpesvirus latency in koi.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 130 citations in OpenAlex.
- Lake Trout (Viruses · 2025Article
- Investigation of β-Carboline Alkaloid Harmaline AgainstViruses · 2025Article
- Peripheral B Lymphocyte Serves as a Reservoir for the Persistently Covert Infection of Mandarin FishViruses · 2024Article
- A review of latency in the Alloherpesviridae family.Journal of fish diseases · 2024Review
- Genomic and molecular characterization of a cyprinid herpesvirus 2 YC-01 strain isolated from gibel carp.Heliyon · 2024Article
- Transcriptomic Responses to Koi Herpesvirus in Isolated Blood Leukocytes from Infected Common Carp.Viruses · 2024Article
- Disease resistance and infectivity of virus susceptible and resistant common carp strains.Scientific reports · 2024Article
- Acipenserid herpesvirus 2 genome and partial validation of a qPCR for its detection in white sturgeon Acipenser transmontanus.Diseases of aquatic organisms · 2024Article
- Protective effects of immersion immunization of koi withFish and shellfish immunology reports · 2023Article
- The Resistance to Lethal Challenge withViruses · 2023Article
- Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain.Virologica Sinica · 2023Article
- Article
- Article
- Development of an attenuated vaccine against Koi Herpesvirus Disease (KHVD) suitable for oral administration and immersion.NPJ vaccines · 2022Article
- Current status and development prospects of aquatic vaccines.Frontiers in immunology · 2022Review
- Investigation of Cyprinid Herpesvirus 3 (CyHV-3) Disease Periods and Factors Influencing CyHV-3 Transmission in A Low Stocking Density Infection Trial.Animals : an open access journal from MDPI · 2021Article
- Susceptibility of Goldfish to Cyprinid Herpesvirus 2 (CyHV-2) SH01 Isolated from Cultured Crucian Carp.Viruses · 2021Article
- A Seasonal Study of Koi Herpesvirus and Koi Sleepy Disease Outbreaks in the United Kingdom in 2018 Using a Pond-Side Test.Animals : an open access journal from MDPI · 2021Article
- Seroconversion and Skin Mucosal Parameters during Koi Herpesvirus Shedding in Common Carp,International journal of molecular sciences · 2020Article
- Evaluation of Cyprinid Herpesvirus 2 Latency and Reactivation inMicroorganisms · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Koi herpesvirus (KHV) has recently been classified as a member of the family of Alloherpesviridae within the order of Herpesvirales. One of the unique features of Herpesviridae is latent infection following a primary infection. However, KHV latency has not been recognized. To determine if latency occurs in clinically normal fish from facilities with a history of KHV infection or exposure, the presence of the KHV genome was investigated in healthy koi by PCR and Southern blotting. KHV DNA, but not infectious virus or mRNAs from lytic infection, was detected in white blood cells from investigated koi. Virus shedding was examined via tissue culture and reverse transcription-PCR (RT-PCR) testing of gill mucus and feces from six koi every other day for 1 month. No infectious virus or KHV DNA was detected in fecal secretion or gill swabs, suggesting that neither acute nor persistent infection was present. To determine if KHV latent infections can be reactivated, six koi were subjected to a temperature stress regime. KHV DNA and infectious virus were detected in both gill and fecal swabs by day 8 following temperature stress. KHV DNA was also detectable in brain, spleen, gills, heart, eye, intestine, kidney, liver, and pancreas in euthanized koi 1 month post-temperature stress. Our study suggests that KHV may become latent in leukocytes and other tissues, that it can be reactivated from latency by temperature stress, and that it may be more widespread in the koi population than previously suspected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.