ArticleDevelopment (Cambridge, England)2011
Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- A NON-CANONICAL ROLE FOR NOTCH3 IN BUILDING THE INTESTINAL LYMPHATIC NICHE.bioRxiv : the preprint server for biology · 2026Article
- Article
- Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer.Acta medica Lituanic · 2019Article
- Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation.Biomedicines · 2018Review
- Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development.Nature genetics · 2016Article
- Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells.The Journal of biological chemistry · 2015Article
- Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms.Oncotarget · 2015Article
- Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1.Canadian journal of gastroenterology & hepatology · 2015Review
- Therapeutic modulation of Notch signalling--are we there yet?Nature reviews. Drug discovery · 2014Review
- The immunological synapse: the gateway to the HIV reservoir.Immunological reviews · 2013Review
- A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells.Development (Cambridge, England) · 2013Article
- Non-canonical Notch signaling: emerging role and mechanism.Trends in cell biology · 2012Review
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Authors and funding
4 authors.
Funding
Abstract
There is increasing evidence for close functional interactions between Wnt and Notch signalling. In many instances, these are mediated by convergence of the signalling events on common transcriptional targets, but there are other instances that cannot be accounted for in this manner. Studies in Drosophila have revealed that an activated form of Armadillo, the effector of Wnt signalling, interacts with, and is modulated by, the Notch receptor. Specifically, the ligand-independent traffic of Notch serves to set up a threshold for the amount of this form of Armadillo and therefore for Wnt signalling. In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. However, genetic experiments suggest that the loss of function of any of these three elements does not have the same effect as elevating the activity of β-catenin. Here, we show that Axin and Apc, but not GSK3, modulate the ligand-independent traffic of Notch. This finding helps to explain unexpected differences in the phenotypes obtained by different ways of activating Armadillo function and provides further support for the notion that Wnt and Notch signalling form a single functional module.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.