ArticleDevelopment (Cambridge, England)2011
The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The neurodevelopmental genes alan shepard and Neuroglian contribute to female mate preference in African Drosophila melanogaster.Journal of evolutionary biology · 2024Article
- Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila.PLoS biology · 2023Article
- The making of the Drosophila mushroom body.Frontiers in physiology · 2023Review
- The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.PLoS genetics · 2021Article
- Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.Stem cell reports · 2021Article
- Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation ofFrontiers in endocrinology · 2021Article
- Untangling the wires: development of sparse, distributed connectivity in the mushroom body calyx.Cell and tissue research · 2021Review
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Characterization of plexinA and two distinct semaphorin1a transcripts in the developing and adult cricket Gryllus bimaculatus.The Journal of comparative neurology · 2020Article
- The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori.Scientific reports · 2017Article
- The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila.Molecular brain · 2017Article
- Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9.Genetics · 2016Article
- Genealogical correspondence of a forebrain centre implies an executive brain in the protostome-deuterostome bilaterian ancestor.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Axon Branch-Specific Semaphorin-1a Signaling in Drosophila Mushroom Body Development.Frontiers in cellular neuroscience · 2016Article
- The Drosophila ortholog of the Zc3h14 RNA binding protein acts within neurons to pattern axon projection in the developing brain.Developmental neurobiology · 2016Article
- L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.The Journal of cell biology · 2015Article
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- Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian.PLoS biology · 2013Article
- Differential effects of human L1CAM mutations on complementing guidance and synaptic defects in Drosophila melanogaster.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The spatiotemporal integration of adhesion and signaling during neuritogenesis is an important prerequisite for the establishment of neuronal networks in the developing brain. In this study, we describe the role of the L1-type CAM Neuroglian protein (NRG) in different steps of Drosophila mushroom body (MB) neuron axonogenesis. Selective axon bundling in the peduncle requires both the extracellular and the intracellular domain of NRG. We uncover a novel role for the ZO-1 homolog Polychaetoid (PYD) in axon branching and in sister branch outgrowth and guidance downstream of the neuron-specific isoform NRG-180. Furthermore, genetic analyses show that the role of NRG in different aspects of MB axonal development not only involves PYD, but also TRIO, SEMA-1A and RAC1.
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