ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2011
Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Association between atherosclerosis and Alzheimer's disease: A systematic review and meta-analysis.Brain and behavior · 2020Pooled it
- Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years.Journal of the American College of Cardiology · 2016Trial
- SNAP MRI Reveals Association Between Distal Cerebral Arterial Flow and Cognitive Function in an Aging Population.bioRxiv : the preprint server for biology · 2026Article
- Cardiovascular risk factors and vascular neuropathological findings in primary age-related tauopathy versus Alzheimer's disease.GeroScience · 2026Article
- Intracranial atherosclerosis increases risk of incident dementia in middle-aged general population.Chinese medical journal · 2026Article
- A vascular component to the selective vulnerability of the medial temporal lobe to tau pathology.Brain communications · 2026Article
- Intracranial stenosis and longitudinal progression of Alzheimer's disease pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- High level expression of OSBPL11 is associated with atherosclerosis and Alzheimer's disease.Inflammation · 2025Article
- Quantitative analysis of cerebral vasculature and its clinical effect on cognitive change in Alzheimer's dementia and mild cognitive impairment.Journal of the neurological sciences · 2025Article
- Prevalence of Cerebral Amyloid Angiopathy and Associated Risk of Subsequent Ischemic and Hemorrhagic Stroke and Mortality in a Nationwide Cohort.Annals of neurology · 2025Article
- Risk prediction for elderly cognitive impairment by radiomic and morphological quantification analysis based on a cerebral MRA imaging cohort.European radiology · 2025Article
- Cholesterol-modifying strategies for Alzheimer disease: promise or fallacy?Expert review of neurotherapeutics · 2025Review
- Trajectories of Cognitive Change and Their Association with All-Cause Mortality Among Chinese Older Adults: Results from the Chinese Longitudinal Healthy Longevity Survey.Behavioral sciences (Basel, Switzerland) · 2025Article
- Lack of intracranial atherosclerosis in various atherosclerotic mouse models.Vascular biology (Bristol, England) · 2025Article
- Article
- Intracranial atherosclerotic disease and neurodegeneration: a narrative review and plausible mechanisms.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Review
- Review
- Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities).Circulation · 2024 · on this mapArticle
- There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Cerebral perivascular spaces as predictors of dementia risk and accelerated brain atrophy.medRxiv : the preprint server for health sciences · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundA substantial body of evidence collected from epidemiologic, correlative, and experimental studies strongly associates atherosclerotic vascular disease (AVD) with Alzheimer's disease (AD). Depending on the precise interrelationship between AVD and AD, systematic application of interventions used to maintain vascular health and function as a component of standard AD therapy offers the prospect of mitigating the presently inexorable course of dementia. To assess this hypothesis, it is vital to rigorously establish the measures of AVD that are most strongly associated with an AD diagnosis.
methodsA precise neuropathological diagnosis was established for all subjects, using a battery of genetic, clinical, and histological methods. The severity of atherosclerosis in the circle of Willis was quantified by direct digitized measurement of arterial occlusion in postmortem specimens and was compared between AD and nondemented control groups by calculating a corresponding index of occlusion.
resultsAtherosclerotic occlusion of the circle of Willis arteries was more extensive in the AD group than in the nondemented control group. Statistically significant differences were also observed between control and AD groups with regard to Braak stage, total plaque score, total neurofibrillary tangle score, total white matter rarefaction score, brain weight, Mini-Mental State Examination scores, and apolipoprotein E allelic frequencies.
conclusionsOur results, combined with a consideration of the multifaceted effects of impaired cerebral circulation, suggest an immediate need for prospective clinical trials to assess the efficacy of AD prevention using antiatherosclerotic agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.