Evidence map›Paper›PMID 21388594›Full record

ArticleJournal of studies on alcohol and drugs2011

Genetic correlation and gene-environment interaction between alcohol problems and educational level in young adulthood.

Antti Latvala, Danielle M Dick, Annamari Tuulio-Henriksson, Jaana Suvisaari, Richard J Viken, Richard J Rose, Jaakko Kaprio

Open access · bronzeAbstract readTwin Study
In one paragraph

Article in Journal of studies on alcohol and drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 citations in OpenAlex.

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  8. FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Antti LatvalaDepartment of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. antti.latvala@thl.fi
Danielle M Dick
Annamari Tuulio-Henriksson
Jaana Suvisaari
Richard J Viken
Richard J Rose
Jaakko Kaprio
Finnish Institute for Health and Welfare · FI

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
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BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIESR01AA009203 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1994 to 1998
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NIAAA NIH HHS AA-09203NIAAA NIH HHS AA-12502NIAAA NIH HHS AA-15416NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502
6 · The paper itself

Abstract

objectiveA lower level of education often co-occurs with alcohol problems, but factors underlying this co-occurrence are not well understood. Specifically, whether these outcomes share part of their underlying genetic influences has not been widely studied. Educational level also reflects various environmental influences that may moderate the genetic etiology of alcohol problems, but gene-environment interactions between educational attainment and alcohol problems are unknown.

methodWe studied the two non-mutually exclusive possibilities of common genetic influences and gene-environment interaction between alcohol problems and low education using a population-based sample (n = 4,858) of Finnish young adult twins (M(age) = 24.5 years, range: 22.8-28.6 years). Alcohol problems were assessed with the Rutgers Alcohol Problem Index and self-reported maximum number of drinks consumed in a 24-hour period. Years of education, based on completed and ongoing studies, represented educational level.

resultsEducational level was inversely associated with alcohol problems in young adulthood, and this association was most parsimoniously explained by overlapping genetic influences. Independent of this co-occurrence, higher education was associated with increased relative importance of genetic influences on alcohol problems, whereas environmental factors had a greater effect among twins with lower education.

conclusionsOur findings suggest a complex relationship between educational level and alcohol problems in young adulthood. Lower education is related to higher levels of alcohol problems, and this co-occurrence is influenced by genetic factors affecting both phenotypes. In addition, educational level moderates the importance of genetic and environmental influences on alcohol problems, possibly reflecting differences in social-control mechanisms related to educational level.

Indexed as

Social EnvironmentAlcohol DrinkingAlcoholismEducational StatusEnvironmentEthanolFemaleHumansMalePhenotypePsychiatric Status Rating ScalesSurveys and QuestionnairesTime FactorsTwinsWhite PeopleYoung AdultEthanol

Identifiers

PMID21388594
PMCPMC3052891
OpenAlexW1428768182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.